Abstract 17088: Less Than Ideal Cardiovascular Health is Associated With Shorter Leukocyte Telomere Length: The National Health and Nutrition Examination Surveys
Introduction: The associations between individual cardiovascular disease (CVD) risk factors and leukocyte telomere length (LTL) have been inconclusive. This study examined the association between global cardiovascular health (CVH) as defined by American Heart Association and LTL.
Hypothesis: We hypothesize that less than ideal CVH is associated with shorter LTL. We also hypothesize the association is modified by gender and racial/ethnicity. In addition, we hypothesize that adjusting for inflammation attenuates the association between CVH and LTL.
Methods: Data were obtained from the 1999-2002 National Health and Nutrition Examination Survey (n= 5194). CVH was defined as a composite score of the 7 metrics (smoking, physical activity, diet, body mass index, blood pressure, total cholesterol, fasting blood glucose) and categorized as “poor”, “intermediate”, and “ideal”. LTL was assayed from whole blood using the quantitative PCR method relative to standard reference DNA. Multivariable linear regression models were used to estimate the association between CVH and log-transformed LTL.
Results: There was strong and graded association between CVH and LTL in the overall sample. Individuals with poor or intermediate CVH was significantly associated with shorter LTL compared to ideal CVH [β =-0.034 (SE=0.013), p=0.011 and -0.024 (0.01), p=0.024, respectively], after adjustment for age, gender, race/ethnicity, marital status, nativity, socioeconomic status, and inflammation. The association was stronger in women [β =-0.066 (0.018), p=0.001 for poor vs. ideal CVH, and -0.051 (0.01), p<0.001 for intermediate vs. ideal CVH] and in white [β =-0.043 (0.014), p=0.004 for poor vs. ideal CVH, and -0.029 (0.012), p<0.017 for intermediate vs. ideal CVH].
Conclusions: Our findings suggest that global CVH is associated with cellular aging, but this association varies by gender and race/ethnicity. Additional research is needed to clarify the mechanisms that underlie these differences.
Author Disclosures: S.Y. Gebreab: None. Z.G. Manna: None. R.J. Khan: None. P. Riestra: None. R. Xu: None. S.K. Davis: None.
- © 2016 by American Heart Association, Inc.