Abstract 16980: Walking Training Improves Local Inflammation and Blood Pressure in Patients With Intermittent Claudication: Preliminary Data
Introduction: Patients with intermittent claudication (IC) present limited walking capacity and increased cardiovascular risk, which are associated with inflammatory markers and hemodynamic alterations. Walking training (WT) is recommended for these patients due to the improvements in the walking capacity, however, its effect on local inflammation and cardiovascular function need to be clarified. Thus, the aim of the present study was to evaluate, in individuals with IC, the effects of the WT on cardiovascular function and inflammation.
Methods: Fifteen men with IC were randomly allocated in two groups: WT (2 sessions/week, 15 bouts of 2 min walking with 2 min of passive pause) and control group (CG - 2 sessions/week, 30 min of stretching). Before and after 12 weeks of the study, walking capacity (total walking distance), blood pressure - BP (auscultatory), heart rate - HR (ECG) and inflammatory markers (vascular cell adhesion molecule - VCAM and intercellular adhesion molecules - ICAM) were measured. Data were evaluated by 2-way ANOVA, with P <0.05 as significant.
Results: Walking capacity improved only in WT (pre: 567 ± 196 m vs post 904 ± 284 m; P<0.05). Compared with pre-intervention, systolic BP decreased in WT (pre: 137 ± 6 mmHg vs post: 127 ± 7 mmHg; P<0.05) but did not change in CG (p>0.05). Diastolic BP and HR did not chance in either group (p>0.05). ICAM decreased in the WT and increased in CG, while VCAM increased only in CG. Thus, post-intervention values of ICAM and VCAM differered between the groups (p<0.05) (Figure 1).
Conclusion: WT improves walking capacity and reduces local inflammation and systolic BP, which may reduce cardiovascular risk in patients with IC.
- Exercise tests and training
- Vascular disease
- Peripheral artery disease (PAD)
- Inflammation and inflammatory markers
Author Disclosures: A. Andrade Lima: None. M. Chehuen: None. N. Silva Jr: None. L. Costa: None. N. Wolosker: None. C. Forjaz: None.
- © 2016 by American Heart Association, Inc.