Abstract 16823: Family History of Heart Failure is Associated With Increased Risk of Heart Failure After First Myocardial Infarction in the Young: a Nationwide Cohort Study
Introduction: A family history of myocardial infarction (MI) is an independent risk factor for MI, however there is a paucity regarding a family history of heart failure (HF) due to MI. We aimed to investigate the risk of HF after first MI in 1. degree relatives to patients with MI induced HF (MI+HF) and to patients with MI but without HF (MI%HF).
Method: Through nationwide registries, we identified all individuals (>18-50 years) hospitalized with primary MI during 1997-2012 in Denmark, and their corresponding 1. degree relatives (study cohort). The cohort was followed 3 years until HF, second MI, death or the end of 2012. Cumulative incidences showing the competing risks were constructed with the endpoints HF, second MI or death, and hazard ratios (HR) were estimated by multivariable Cox regression models adjusted for age, sex, comorbidity and cardiovascular medications.
Results: We found 10,223 patients with primary MI, of which 506 (5%), 2,540 (25%), and 7,177 (70%) patients had ≥1 relative previously hospitalized with MI+HF, MI%HF or had no family history of MI, respectively. Cumulative incidences of HF at 3 years were 14% (95% CI 11-17%), 12% (95% CI 10-13%), and 11% (95% CI 10-12%) in 1. degree relatives with a family history of MI+HF, MI%HF, and with no family history of MI, respectively. Having a sibling with MI+HF or MI%HF was associated with an increased risk of HF compared with siblings without a family history of MI (HR 3.04, 95% CI 1.44-6.42 and HR 1.46, 95% CI 1.06-2.02). Furthermore, having a father with MI+HF was associated with an increased risk of HF (HR 1.36, 95% CI 1.01-1.83) (Fig. 1).
Conclusion: Having a 1. degree relative with MI induced HF was associated with an increased risk of HF after hospitalization with first-time MI. The highest risk was observed when the relative was a sibling. This study highlights an important issue for the physicians when counseling patients with first MI and a family history of HF, and suggests a genetic component to the susceptibility of HF after MI.
Author Disclosures: C. Glinge: None. L. Oestergaard: None. R. Jabbari: None. R. Skals: None. C. Jespersen: None. T. Engstrøm: None. C. Torp-Pedersen: None. G. Gislason: None. J. Tfelt-Hansen: None.
- © 2016 by American Heart Association, Inc.