Abstract 16808: Relationship of Kidney Injury Molecule-1 With Estimated Glomerular Filtration Rate and Blood Pressure in the General Population
Background: Prior reports have shown that kidney injury molecule-1 (KIM-1) is increased among individuals with renal diseases. Currently, little is known about the role and function of KIM-1 in individuals with normal kidney function. Therefore, the aim of this study was to evaluate the relationship of KIM-1 with kidney function and blood pressure (BP) in young and healthy adults.
Methods: Healthy individuals aged 25 to 41 years were enrolled in a population-based cohort study. Main exclusion criteria were a BMI>35kg/m2, or known kidney or cardiovascular disease. Creatinine was assayed from a fasting venous blood sample and estimated glomerular filtration rate (eGFR) calculated using the creatinine based CKD-EPI formula. KIM-1 was measured from frozen plasma samples using a high-sensitivity assay. Conventional and 24-hour (h) BP was measured under standardized conditions. Multivariable linear regression analyses were constructed and adjusted for a broad set of potential confounders.
Results: We included 2070 individuals (47% men) with a median age of 36.8 years in this analysis. Median levels of KIM-1 and eGFR were 82.5 (IQR 59.4-112.7) pg/ml and 112 (103; 118) ml/min, respectively. Mean systolic and diastolic 24-h BP were 123±12 and 79±8 mmHg. After multivariable adjustment, there was a significant relationship between log-transformed KIM-1 and eGFR. Further, we found linear relationships of KIM-1 with systolic and diastolic BP, as presented in the Table. Per 1-mmHg increase in BP, log-transformed KIM-1 increased by 0.06 (95% CI 0.03; 0.08), p<0.0001 for systolic 24-h BP, 0.05 (0.02; 0.08), p=0.02 for diastolic 24-h BP 0.04 (0.02; 0.06), p=0.0003 for systolic conventional BP and 0.04 (0.01; 0.07), p=0.003 for diastolic conventional BP.
Conclusion: Among young and healthy adults, plasma levels of KIM-1 were independently associated with renal function as well as with systolic and diastolic BP. KIM-1 may therefore be a very early marker of BP-induced kidney injury.
Author Disclosures: P. Egli: None. S. Aeschbacher: None. M. Bossard: None. L. Eggimann: None. L. Bargetzi: None. J. Estis: Employment; Significant; Employee Singulex. J. Todd: Employment; Significant; Employee Singulex. M. Risch: None. L. Risch: None. D. Conen: None.
- © 2016 by American Heart Association, Inc.