Abstract 16775: Glycemic Variability Correlated With Vascular Stiffness and LV Filling Pressure at 1 Year After Onset of First ST-segment Elevation Myocardial Infarction: MRI and Tissue Doppler Analysis
Introduction: Glycemic Variability (GV) may play an important role in patients with ST-segment elevation myocardial infarction (STEMI). But the clinical significance of GV is not fully understood in patients with a first STEMI.
Methods: Consecutive 148 patients with a first STEMI (64±12 years, 88% male, max CPK=2964 IU/L, LAD 80/LCX 15/RCA 53), who had undergone reperfusion therapy within 12 hours after onset were enrolled. We analyzed GV by a continuous glucose monitoring system (CGM: iPRO2, Medtronic) at 2 weeks and mean amplitude of glycemic excursions (MAGE) as the parameter of GV. The infarct size was evaluated by using late-gadolinium enhancement (CMR-LGE) at 1 week. The cardio-ankle vascular stiffness index (CAVI) is not affected by blood pressure at the time of examination, thereby we examined CAVI at 2 weeks as the parameter of arterial stiffness. We assessed cardiac function measured by echocardiography and BNP at 12 months from discharge. E/e’ was measured as the marker of left ventricular (LV) filling pressure.
Results: MAGE had significant relationship with CAVI (r=0.177; p<0.05) and was positively correlated with E/e’ (r=0.209 p<0.05) and BNP (r=0.226; p<0.05) at 12 months. Table shows the regression analysis for E/e’ at 12 months, and MAGE and CAVI were the significant parameters, however HbA1c or admission glucose were not.
Conclusions: MAGE correlated with arterial stiffness and predicted elevated LV filling pressure at 12 months in patients with a first STEMI.
Author Disclosures: J. Kirigaya: None. N. Iwahashi: None. H. Takahashi: None. Y. Minamimoto: None. Y. Matsuzawa: None. K. Hashiba: None. N. Maejima: None. K. Hibi: None. T. Ebina: None. M. Kosuge: None. K. Kimura: None.
- © 2016 by American Heart Association, Inc.