Abstract 16761: The Relationship of Lipids and Lipoprotein Distribution With Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis
Introduction: Previous studies suggest lower concentrations of both total and HDL cholesterol to be predictive of depression. We therefore investigated the relationship of lipids and lipoprotein distribution with elevated depressive symptoms (EDS) in healthy men and women from the Multi-Ethnic Study of Atherosclerosis (MESA).
Methods: All MESA participants were 45-84 years old and free of clinically apparent cardiovascular disease at baseline. They were recruited from six United States communities and were followed up in person at four clinic visits over a 9.5-year period. EDS were defined as a Center for Epidemiological Studies Depression (CES-D) score ≥16 and/or use of antidepressant drugs. Lipoprotein distribution was determined from plasma by nuclear magnetic resonance spectroscopy.
Results: Among 4938 MESA participants without EDS at baseline, 1178 participants (23.9%) developed EDS during follow-up. In multivariable Cox regression analyses, lower total, LDL, and non-HDL cholesterol concentrations at baseline were associated with incident EDS over 9.5 years (hazards ratio = 1.11-1.12 per SD decrease, all P<0.01), after adjusting for demographic factors, traditional risk factors including LDL cholesterol, HDL cholesterol and triglycerides, and lipid-lowering medication. Lipoprotein particle subclasses and sizes were not associated with incident EDS. Among participants not taking antidepressant drugs at baseline and the last clinical visit, lower concentrations of total cholesterol, LDL cholesterol and non-HDL cholesterol at baseline were associated with an increase in CES-D score from baseline to last visit (all p=0.02). Among participants without EDS at both baseline and visit 3, a smaller increase in total or non-HDL cholesterol between these visits was associated with lower risk of incident EDS after visit 3 (hazards ratio = 0.88-0.90 per SD decrease, P<0.05).
Conclusions: Lower baseline concentrations of total, LDL and non-HDL cholesterol were associated with a higher risk of incident EDS. However, a short-term increase in cholesterol concentrations did not help to reduce the risk of EDS. Further studies are needed to replicate our findings and clarify the contradictory relationship between lipid profile and depression.
Author Disclosures: K. Ong: None. M.J. Morris: None. R.L. McClelland: None. J. Maniam: None. M.A. Allison: None. K. Rye: None.
- © 2016 by American Heart Association, Inc.