Abstract 16735: Effect of Communicating Phenotypic and Genetic Risk of Coronary Heart Disease Alongside Web-based Lifestyle Advice - The Inform Randomized Clinical Trial
Introduction: Coronary heart disease (CHD) risk scores based on phenotypic information are routinely used in primary care. It has been suggested that genetics could be used to more precisely identify individuals at high risk of developing disease and to more effectively motivate individuals to change their lifestyle. However, there is a lack of adequately powered randomized trials using objective measures to evaluate the effect of provision of phenotypic and genetic CHD risk information on health behaviours.
Hypothesis: We aimed to quantify the short-term (12 weeks) effects of provision of phenotypic and genetic CHD risk information, alongside lifestyle advice, on change in objectively-measured health behaviours and cardiovascular risk factors.
Methods: In a parallel-group, open randomized trial, we allocated 956 male and female blood donors (mean (SD) age = 56.7 (8.8)) with no previous history of CHD to either no intervention (control group) or to one of three active intervention groups: i) web-based lifestyle advice only; ii) lifestyle advice plus information on estimated 10-year CHD risk based on phenotypic characteristics; and iii) lifestyle advice plus information on estimated 10-year CHD risk based on phenotypic and genetic characteristics. The primary outcome was change in physical activity from baseline to 12 weeks (mean acceleration over 7 days measured by Axivity Accelerometer®). Secondary key outcome was: change in fruit and vegetable intake measured by serum carotenoids.
Results: 928 (97.1%) participants completed the trial. There was no evidence of intervention effects on physical activity. There were also no evidence of intervention effects on serum carotenoids (difference in adjusted mean change from baseline): lifestyle advice only group vs control group 0.11μmol/l (95% CI: -0.04 to 0.26); genetic group vs phenotypic group -0.15μmol/l (95% CI: -0.30 to 0.00); phenotypic group and genetic group vs. control group 0.05μmol/l (95% CI: -0.08 to 0.18) and phenotypic group and genetic group vs. lifestyle group -0.07μmol/l (95% CI: -0.20 to 0.07).
Conclusions: Provision of CHD risk information (based on phenotype or genotype) and web-based lifestyle advice are unlikely to enhance preventive strategies by influencing health behaviours.
Author Disclosures: B. Silarova: None. S.J. Sharp: None. J.A. Usher-Smith: None. J. Lucas: None. R.A. Payne: None. G. Shefer: None. C. Moore: None. C. Girling: None. K. Lawrence: None. Z. Tolkien: None. M. Walker: None. A.S. Butterworth: None. E. Di Angelantonio: None. J. Danesh: None. S. Griffin: None.
- © 2016 by American Heart Association, Inc.