Abstract 16471: Increased Serum Soluble Hemoglobin Scavenger Receptor Levels are related to the Protective Effect of Ventricular Remodeling After Reperfusion in Patients With ST-elevation Myocardial Infarction
Background: The soluble form of hemoglobin scavenger receptor CD163 (sCD163) is a normal constituent of blood and is generated by proteolytic cleavage of CD163 at the cell surface. In this study, we investigated whether serum sCD163 levels are associated with LV remodeling after reperfusion in patients with ST-elevation myocardial infarction (STEMI).
Methods: Serum sCD163 levels were measured in patients with STEMI (n=169), who underwent primary angioplasty within 24 hours of symptom onset. Measurements were taken at the acute phase (within 24 hours of STEMI onset) and at the chronic phase (14 days after STEMI onset), and the findings were related to LV remodeling following STEMI. Left ventriculography was performed at the acute phase and at 6 months after STEMI, and left ventricular end-diastolic volumes were calculated. In addition, we immunohistochemically examined the expression of CD163 in the infarcted myocardium from 11 autopsied patients, who died 1-14 days after the onset of STEMI.
Results: Serum sCD163 levels at the chronic phase were elevated compared with the acute phase (689.9±240.1 vs. 745.0±256.8 ng/ml, P<0.0001). Twenty-seven patients (16%) showed LV remodeling (≥20% increase in end-diastolic volume). Serum sCD163 at the chronic phase was significantly lower in the remodeling group than in the non-remodeling group (603.4±135.3 vs. 770.8±265.4 ng/ml, P<0.005). Multiple regression analysis showed that low serum CD163 levels (< 692.1 ng/ml, median) at the chronic phase were a significant independent predictor of LV remodeling (odds ratio: 3.04, 95% confidence interval: 1.05-8.79, P=0.04). Immunohistochemical staining showed that the percentage of the CD163-positive area in the infarcted myocardium was significantly higher (P<0.01) in the chronic phase (7-14 days after STEMI onset) than in the acute phase (1- 4 days after STEMI onset). Double immunostaining for CD163 and macrophages revealed that the vast majority of CD163-positive cells were macrophages.
Conclusions: These findings suggest that increased expression and serum levels of CD163 at the chronic phase are associated with a protective effect of ventricular remodeling after reperfusion in patients with ST-elevation myocardial infarction.
Author Disclosures: T. Matsushita: None. Y. Mastumura: None. T. Yoshiyama: None. K. Simeno: None. R. Mastumoto: None. Y. Abe: None. K. Kamimori: None. T. Naruko: None. K. Sugioka: None. M. Nakagawa: None. M. Yoshiyama: None. M. Ueda: None.
- © 2016 by American Heart Association, Inc.