Abstract 16403: Association Between Dietary Saturated Fat Intake, Coronary Artery Calcification, and Mortality
Background: Multiple epidemiologic studies have linked diet to cardiovascular disease (CVD) prevention, with dietary guidelines recommending restricting intake of saturated fats (SatFat) due to observations that they raise levels of total serum cholesterol. Whether diet impacts atherosclerosis and coronary calcium remains controversial. This study evaluates the correlation between self-reported dietary SatFat, coronary artery calcium (CAC) and long-term mortality.
Methods: We studied 14,400 non-diabetic asymptomatic patients who had CAC scans between 1998 and 2012. All completed a baseline history and risk factor questionnaire with self reported adherence to a low SatFat diet on a 10 point scale (10 = strict adherence). SatFat scores were categorized as low (8-10), intermediate (3-7) and high (0-2). Height, weight, blood pressure, and serum lipid profile were measured. Mortality data were available for 10,540 (75%). Analysis was adjusted for age, sex, BMI, smoking, hyperlipidemia, hypertension, statin use, family history, and calcium score.
Results: Median follow-up was 9.5 years. SafFat intake was low, intermediate, and high in 21.9%, 58.5%, and 19.6% patients respectively. Mean total cholesterol was lower with low SatFat diet (198, SD 41.7) compared to high SatFat diet (205, SD 42.0), p<0.001. Mean LDL was lower with low SatFat diet (119, SD 35.5) compared to high SatFat diet (128, SD 46.6), p<0.001. There was no significant difference in CAC score between the three groups (p = 0.08). In multivariate analysis, low and medium SatFat diet were associated with a reduced risk of all-cause mortality compared to patients with high SatFat diets (p<0.001).
Conclusion: Patients reporting low SatFat diets do not have lower CAC scores, despite having lower LDL and total cholesterol. A diet high in SatFat is, however, associated with increased overall mortality.
Author Disclosures: A. Lajoie: None. Y. Arnson: None. H. Gransar: None. L.E. Thomson: None. J.D. Friedman: None. S.W. Hayes: None. A. Rozanski: None. D.S. Berman: None.
- © 2016 by American Heart Association, Inc.