Abstract 16370: Short Term Effects of Photochemical Oxidant on Heart Failure: A Case-Crossover Study
Introduction: The cardiovascular health consequences of ambient air pollution generally equal or exceed those due to pulmonary diseases and cancers. However, few studies have determined culprit air pollutant for heart failure incidence. Over the past decade, fine particles <2.5μm in aerodynamic diameter (PM2.5), and gases (e.g. photochemical oxidant (OX), nitric oxide(NO) and nitrogen dioxide(NO2)) have become a major focus of research. The most infamous component of photochemical oxidant is known as ozone. This study aimed to identify the associations between incidence of heart failure and air pollutants including PM2.5, NO, NO2 and Ox.
Methods: The association between air quality and heart failure was evaluated using a case-crossover design in Gunma Prefecture (population ~2million; area 6,363km2), Japan. Incident cases with heart failure were identified through the Gunma Prefectural Ambulance Activity Database in 2015. Air quality data from the nearest station (among eight 24-hr monitoring) was for day of the event (lag 0) and for lag 1, lag 2, and lag 3. Conditional logistic regression was used for unadjusted analysis and adjusted for temperature and humidity.
Results: There were 1002 heart failures among the total of 53006 emergency cases from January to December in 2015. Daily lag1 OX level had significant association with incidence of heart failure in both unadjusted (OR: 1.003; 95%CI: 1.000, 1.005; p value: 0.017) and adjusted (OR: 1.003; 95%CI: 1.000, 1.005; p value: 0.026) model. No effects were found for PM2.5, NO and NO2.
Conclusions: The increased risk of heart failure is associated with photochemical oxidant level of 1 day before the event but not with PM2.5, NO and NO2.
Author Disclosures: B. Zhao: None. F. Salimi: None. F. Johnston: None. K. Oshima: None. M. Kurabayashi: None. K. Negishi: None.
- © 2016 by American Heart Association, Inc.