Abstract 16275: Out-of-Hospital Cardiac Arrest and Short-Term Exposure to Air Pollutants: A Case-Crossover Study
Introduction: Over the past decade, particulate matter (PM), such as fine particles <2.5μm in aerodynamic diameter (PM2.5) has become a major focus of research although gases like, photochemical oxidant(OX) and nitrogen Oxides(NOX), may cause disease individually or in combination with PM. On a global scale, >3 million premature deaths occur per year and 76 million disability-adjusted life-years are lost annually due to ambient PM exposure. However, the evidence regarding the association between air pollution and acute cardiac events, such as out-of-hospital cardiac arrest (OHCA), is inconsistent. This study aimed to identify the associations between incidence of OHCA with air pollutants including PM2.5, Ox and NOX.
Methods: The association between air quality and OHCA was evaluated using a case-crossover design in Gunma Prefecture (population ~2million; area 6,363km2), Japan. OHCA cases were identified through the Gunma Prefectural Ambulance Activity Database in 2015. Our exclusion criteria were: arrests with an obvious preceding noncardiac event such as trauma, poisoning, or drowning, leaving only those events that were presumed to have cardiac etiology. Air quality data from the nearest station (among eight 24-hr monitoring) was for day of the arrest (lag 0) and for lag 1, lag 2, and lag 3. Conditional logistic regression was used for unadjusted analysis and adjusted for temperature and humidity.
Results: There were 1512 OHCAs among the total of 53006 emergency ambulance cases from January to December in 2015. Daily lag3 PM2.5 level had significant association with incidence of OHCA in both univariable (OR: 1.003; 95%CI: 1.000, 1.005; p value: 0.019) and multivariable (OR: 1.003; 95%CI: 1.001, 1.005; p value: 0.014) model (Table). No effects were found for OX and NOX.
Conclusions: The risk of OHCA was associated with daily PM2.5 level of 3 days before the event but not with other air pollutants.
Author Disclosures: B. Zhao: None. F. Salimi: None. F. Johnston: None. K. Oshima: None. M. Kurabayashi: None. K. Negishi: None.
- © 2016 by American Heart Association, Inc.