Abstract 16261: Longitudinal Study of Alcohol Consumption and High-Density Lipoprotein Concentrations: A Community-Based Study
Introduction: Cross-sectional studies and short-term clinical trials suggest a linear relationship between alcohol consumption and high-density lipoprotein (HDL) cholesterol concentrations although prospective data suggests the relationship may be more complex. The association between consumption of alcohol and individual alcohol beverages and longitudinal change in HDL concentrations was examined in a community-based cohort.
Methods: This study included 80,081 Chinese adults (mean age 49 y) who were free of cardiovascular diseases and cancer, and did not use any cholesterol-lowering agents during follow-up. Alcohol intake was assessed by a questionnaire in 2006 (baseline) and participants were categorized as never, past, light (women: 0-0.4 servings/d, men: 0-0.9 servings/d), moderate (women: 0.5-1.0 servings/d, men: 1-2 servings/d), and heavy drinkers (women: >1.0 servings/d, men: >2 servings/d). HDL concentrations were measured in 2006, 2008, 2010, and 2012. We used generalized estimating equation models to examine the associations between baseline alcohol intake and change in HDL concentrations, adjusting for age, sex, smoking, physical activity, obesity, hypertension, diabetes, liver function and C-reactive protein concentrations.
Results: An inverted U-shaped association was observed between alcohol consumption and changes in HDL. Compared with never drinkers, past, light, moderate and heavy drinkers, respectively, experienced a 0.012, 0.013, 0.017, and 0.008 mmol/l per year slower decrease rate in HDL (P <0.0001 for all) after adjusting for potential confounders. Moderate alcohol consumption was associated with the slowest increase in total cholesterol/HDL and triglyceride/HDL ratios among all groups. We observed the same association as overall between hard liquor consumption and HDL change. In contrast, greater beer consumption was associated with slower HDL decreases, in a dose-response manner.
Conclusions: Alcohol consumption was associated with slower HDL decreases, with moderate consumption slowest. However, the data suggested differential effects on the basis of alcoholic beverage type.
Author Disclosures: S. Huang: None. J. Li: None. G.C. Shearer: None. A.H. Lichtenstein: None. X. Zheng: None. Y. Wu: None. C. Jin: None. S. Wu: None. X. Gao: None.
- © 2016 by American Heart Association, Inc.