Abstract 16254: Early Detection of Abnormal Carotid Artery Stiffness in Patients With Metabolic Syndrome Using Two Dimensional Speckle Tracking Imaging Feasibility and Accuracy
Objective: The aim of this study was to assess the feasibility and accuracy of two-dimensional Speckle Tracking (2D-STI) in the carotid artery elasticity.
Methods: 85 patients with MS were divided into three sub-groups, MS with hypertension and diabetes (HDMS, n = 27), MS with hypertension (HMS, n = 29), MS with diabetes (DMS, n = 29). Twenty-four age- and gender- matched healthy volunteers were enrolled as control group (Con.). In 2D-STI, the following values of left common carotid (LCCA )were measured: The global and segmental peak systolic circumferential strain (CAS), four time interval according to the Electrocardiogram from carotid strain curve : Predistension time(PDT), Arterial distension Period(ADP), peak CAS time(PST)and arterial diastolic time(ADT). All the time indices were normalized for cardiac cycle length. E-Tracking imaging was performed to assess the carotid stiffness too.
Results: ①left ventricular mass index (LVMI) were increased in patients with MS when compared with those in controls(P=0.0001), the ratio of E/A was decreased significantly(P=0.039); LCCA stiffness β were increased in MS patients when compared with controls, the values were worse in HDMS patients(P =0.0001); ②In patients with MS, global CAS and the segment CAS of inferior wall and right inferior wall were lower when compared with those in controls ( P=0.0001),Global CAS was further reduced in patients with HDMS compared with HMS and DMS(P=0.02)(Fig.1), Global CAS was significantly inversely correlated with β(r = -0.69, P =0.0001), age (r =-0.52, P =0.0001); ③In patients with MS, the time intervals of PST,PDT and ADP were prolonged, ADT was shorter than those of controls (P=0.002);④The Bland-Altman analysis showed that the coefficient of variation (CV) of inter- and intra-observer of CAS was 5.07% and 5.40%, the CV of inter- and intra-observer of β was 7.83% and 8.92%.
Conclusions: Carotid artery exits abnormal stiffness increase in patients with MS. CAS will further reduce with the progression of MS. Cardiac contraction and stress was significantly delayed and carotid artery retraction time was shortened in MS patients. There is great potential for 2D-STI to early detection and treatment in process of MS and increase the understanding of cardiovascular coupling disease.
Author Disclosures: J. Wang: None. J. Li: None. M. Xie: None.
- © 2016 by American Heart Association, Inc.