Abstract 16243: Dose-response Relationships Between Exercise Intensity, Mood States, and Quality of Life in Heart Failure Patients
Background: The beneficial effects of exercise training on mood disorders and quality of life (QOL) in patients with heart failure (HF) remains controversial, with investigators documenting both positive and negative results. We conducted a secondary analysis to 1) compare changes in mood disorders, specifically anxiety, depression, hostility, and QOL among four groups of patients in a home-based exercise program who had varying degrees of change in their exercise capacity; and 2) determine whether there was an association between exercise capacity, mood disorders, and QOL.
Hypothesis: We assessed the hypothesis that positive changes in mood states and QOL were dependent on the degree to which patients experienced significant improvements in their exercise capacity related to exercise training.
Methods: Seventy-one patients in the exercise arm of a clinical trial were divided into 4 groups based on changes in exercise capacity from baseline to 6 months: Group 1 were patients with improvements >10% (n = 19); Group 2 were patients with improvements ≤ 10% (n = 16); Group 3 were patients with reductions ≤ 10% (n = 9); and Group 4 were patients with reductions >10% (n = 27).
Results: Over time, patients in all four groups demonstrated significantly lower levels of depression and hostility (P<.001) and significantly higher levels of physical and overall QOL (P=.046). Group differences over time were noted in anxiety (P =.009), depression (P =.015), physical QOL (P <.001) and overall QOL (P =.002). Greater improvement in exercise capacity was strongly associated with lower depression scores (r=-.49, P=.01).
Conclusions: In conclusion, an improvement in exercise capacity with exercise training was associated with a decrease in depression and anxiety and an increase in QOL in patients with HF. The controversial findings in prior clinical trials may be the result of variable changes in exercise capacity secondary to non-adherence or other clinical factors.
Author Disclosures: M.C. Cacciata: None. A. Stromberg: None. L. Evangelista: None.
- © 2016 by American Heart Association, Inc.