Abstract 16183: High Circulating Adiponectin is Associated With Poor Long-term Clinical Outcome After Catheter Ablation for Paroxysmal Atrial Fibrillation
Introduction: Adiponectin has anti-diabetic, anti-atherogenic and anti-inflammatory properties, but, many studies exploring the predictive value of adiponectin in cardiovascular disease have yielded opposite results, known as the “adiponectin paradox”. Recently, we reported that overweight and metabolic syndrome have relation with clinical recurrence of atrial fibrillation (AF) 2-years after catheter ablation.
Hypothesis: We hypothesized that the pre-procedural plasma level of adiponectin has a prognostic value in patients who underwent AF catheter ablation.
Methods: This study included 874 patients (73.0% male, 57.6±11.2 years of age) who underwent RFCA for paroxysmal AF, and conducted quartile analyses for pre-procedural plasma levels of adiponectin to determine AF-related clinical factors.
Results: 1. The highest quartile of plasma adiponectin were more likely to be older (p<0.001), and had higher proportions of females (p<0.001) and higher CHA2DS2-VASc scores (p<0.001) than others. 2. Plasma level of adiponectin was independently associated with female gender (B 2.92, 95% CI 1.84 to 4.00, p<0.001), older age (B 0.06, 95% CI 0.03 to 0.10, p<0.001), lower body mass index (B -0.22, 95% CI -0.42 to -0.03, p=0.025), and greater LA volume index (B 0.05, 95% CI 0.01 to 0.08, p=0.005). 3 During the 29.9±18.0 months of follow-up, patients in the highest quartile of plasma adiponectin showed higher clinical recurrence rate than other groups (Kaplan-Meier analysis, log rank p=0.029), and the plasma adiponectin level (HR 1.17, 95% CI 1.02-1.35, p=0.022) was independently associated with clinical recurrence of AF after catheter ablation for paroxysmal AF.
Conclusions: High circulating adiponectin is independently associated with recurrence of AF after catheter ablation for paroxysmal AF.
Author Disclosures: T. Kim: None. J. Lee: None. J. Uhm: None. J. Kim: None. B. Joung: None. M. Lee: None. H. Pak: None.
- © 2016 by American Heart Association, Inc.