Abstract 16080: A Comparison of the Prevalence and Severity of Coronary Artery Calcium Scoring Among Asymptomatic Korean and Chinese Adults
Introduction: Cardiovascular disease is a prominent cause of morbidity and mortality among east Asian countries. Yet, available epidemiologic studies assessing the ethnic disparity in cardiovascular risk within east Asian nations are suboptimal at present.
Hypothesis: To explore differences, if any, in the burden of CAD among asymptomatic Korean and Chinese adults, based on coronary artery calcium scoring (CACS) as a marker of subclinical CAD.
Methods: Data pertaining to two separate cohorts were utilized, consisting of asymptomatic Korean (n=11,494) and Chinese (n=928) adults, for whom CACS was performed as part of a broad health screening examination during 2012 and 2013. Propensity score matching was performed according to: age, gender, hypertension, diabetes, dyslipidemia, and current smoking status, which generated 2 cohorts of 817 matched pairs. CACS was categorized as >0, >100 and >400. Multivariate conditional logistic regression models reporting odds ratios (OR) with 95% confidence intervals (95% CI) was performed to estimate the likelihood of having CAC among Chinese adults, with reference to Korean adults.
Results: For the matched study samples, mean age was 54±7 years, and 53% were male. The prevalence of CACS >400 tended to be higher in asymptomatic Chinese as compared with Korean adults (3.7% vs.1.9%, respectively, P = 0.036). Overall, the adjusted OR for the likelihood of having CACS was similar and non-significant among Chinese adults, with reference to Korean adults (Table). Likewise, the adjusted OR did not differ appreciably between asymptomatic Chinese and Korean adults according to gender subsets (Table).
Conclusions: The prevalence and distribution of CACS displayed no notable differences between asymptomatic Korean and Chinese adults, indicating similar CACS cut-off points may be assigned to both ethnicities for the purpose of CAD risk stratification.
Author Disclosures: D. Han: None. G. Yang: None. B. ó Hartaigh: None. J. Lee: None. S. Choi: None. E. Chun: None. J. Sung: None. S. Park: None. H. Han: None. J.K. Min: None. H. Chang: None.
- © 2016 by American Heart Association, Inc.