Abstract 16077: Increased Pulsatile Arterial Load and Progression of Left Ventricular Longitudinal Systolic Dysfunction in Aortic Stenosis: Results From the PROGRESSA Study
Introduction: Previous studies demonstrated that, compared to LV ejection fraction (LVEF), LV global longitudinal strain (GLS) is a more sensitive marker of subclinical LV dysfunction and provides incremental prognostic value in patients with aortic stenosis (AS). However, there is no data on the progression of LV longitudinal dysfunction during follow-up and its determinants in AS.
Hypothesis: Higher pulsatile arterial load might predict faster decrease of GLS in AS.
Methods: One hundred and twenty consecutive patients with AS were prospectively recruited in the PROGRESSA study and underwent a comprehensive Doppler echocardiography annually. GLS was measured by 2-dimensional speckle-tracking and the annualized change in GLS was calculated. Arterial pulse pressure (PP) was determined by systolic minus diastolic arterial pressure.
Results: Mean age was 64±14 years and there were 68% of men. During a mean follow-up of 2.6±1.3 years, GLS decreased significantly (median [Percentiles 25 - 75]: baseline GLS
Author Disclosures: L.L. Tastet: None. R. Capoulade: None. M. Clavel: None. M. Shen: None. P. Mathieu: None. M. Arsenault: None. É. Bédard: None. J. Beaudoin: None. M. Bernier: None. K. O’Connor: None. J.G. Dumesnil: None. P. Pibarot: None.
- © 2016 by American Heart Association, Inc.