Abstract 16068: Polycythemia Vera is Associated With Increased Atrial Fibrillation Compared to the General Population: Results From the National Inpatient Sample Database
Introduction: Polycythemia vera (PV) is a myeloproliferative disorder characterized by a chronic inflammatory state, which is a known risk factor for cardiovascular disease. Currently, there is a paucity of data on arrhythmias and other cardiovascular complications associated with PV.
Hypothesis: We hypothesize that PV is associated with increased risk of atrial fibrillation (AF).
Methods: All patients above 18 years of age diagnosed with PV were identified in the Nationwide Inpatient Sample (NIS) 2009-2010 database using the 9th revision of International Classification of Diseases (ICD) codes (238.4). Demographic factors, cardiac risk factors, and cardiovascular events were identified. Multivariate logistic regression was performed to evaluate the predictors of AF.
Results: Prevalence of PV was 0.1% (n=37,922) with a mean age of 65.2±0.1 years and 58% males. The prevalence of AF was significantly higher in the PV population compared to the general population (18% vs 11%; p <0.0001). Hypertension, obesity, established CAD and heart failure were significantly higher in patients with PV. Further, PV remained an independent predictor of AF after adjusting for age, sex, diabetes, hypertension, obesity, valvular disease, stroke, hyperthyroidism, established CAD, heart failure, tobacco use, and alcohol use [OR 1.31(1.22-1.40); p=0.000].
Conclusions: PV is an independent predictor of AF even after adjusting for traditional risk factors and cardiovascular events. This warrants increased awareness of AF risk and potential thromboembolic risk in patients with PV. The increased burden of cardiac risk factors in PV also needs to be factored in, necessitating aggressive management and risk stratification of PV patients.
Author Disclosures: P. Krishnamoorthy: None. A. Kalla: None. A. Gopalakrishnan: None. V. Mittal: None. J. Garg: None. N.C. Patel: None. J. Rangaswami: None. V.M. Figueredo: None.
- © 2016 by American Heart Association, Inc.