Abstract 16061: Epicardial Fat Volume Quantification in Acute Pericarditis: Prognostic and Therapeutic Implications
Introduction: The pathophysiology of acute pericarditis remains unknown and novel biomarkers are needed to identify patients susceptible to complications.
Hypothesis: We assumed that quantification of epicardial fat volume (EFV) might provide prognostic information in patients with acute pericarditis.
Methods: Fifty (n=50) patients with first diagnosis of acute pericarditis were enrolled in this study, who were managed according to clinical recommendations. Patients underwent a cardiac computerized tomography (CT) scan to quantify EFV on a dedicated workstation. Patients were followed-up in-hospital for AF development and up to 18 months for the composite clinical endpoint of development of constrictive, recurrent or incessant pericarditis or poor response to NSAIDs treatment.
Results: Patients presenting with chest pain had lower EFV vs. patients without chest pain (167.2 ± 21.7vs 105.1±11.1cm3respectively, p<0.01); EFV (but not body mass index) was strongly positively correlated with pericardial effusion size (r=0.395, p=0.007) and was an independent predictor of in-hospital new atrial fibrillation, even after adjustment for covariates (RR=1.028 [95%CI:1.006-1.052], p<0.05). Importantly, patients with poor response to NSAIDs or those that reached the composite clinical endpoint had lower EFV (p<0.05 for both). After adjustment for age, EFV was independently associated with the composite endpoint of poor response to NSAIDs and/or the development of constrictive, recurrent or incessant pericarditis during follow-up (RR=0.989[95%CI:0.979-0.999], p<0.05).
Conclusions: We report for the first time a significant association of EFV with the clinical features and the outcome of patients with acute pericarditis. Measurement of EFV by CT may have important diagnostic and prognostic implications in these patients.
Author Disclosures: G. Lazaros: None. A. Antonopoulos: None. E.K. Oikonomou: None. P. Vasileiou: None. E. Oikonomou: None. E. Stroumpouli: None. A. Karavidas: None. C. Antoniades: None. D. Tousoulis: None.
- © 2016 by American Heart Association, Inc.