Abstract 16052: Gender Differences in Post-heart Transplant Trajectories of Anxiety, Depressive Symptoms and Health-related Quality of Life
Introduction: Little is known about the role of gender in health-related quality of life (HRQOL), anxiety, and depressive symptoms over time after heart transplant (Htx). Our objective was to describe longitudinal changes in anxiety, depressive symptoms, and HRQOL after Htx and examine gender differences over time.
Methods: We included 113 adult Htx patients (70% male, 50% white, mean age=52.6 ± 13.3 years) from a larger study of home ECG monitoring to predict Htx rejection. Mean time from Htx to enrollment was 52.9 ± 32.7 days. Subjects completed psychosocial questionnaires at 3, 6, and 9 months post-Htx. Anxiety was measured using the anxiety subscale of the Brief Symptom Inventory (BSI). Depressive symptoms were measured using the Patient Health Questionnaire [PHQ]-9. HRQOL was measured by the RAND-36 Health Survey (general health subscale). Statistical analyses included chi-square, t-test, repeated measures ANOVA, and linear regression.
Results: Overall, anxiety (p < .001), depressive symptoms (p < .001), and HRQOL (p = .009) improved over time for both men and women. However, compared to men, women reported significantly higher anxiety and depressive symptoms in the first 6 months after Htx (Figure). By 9 months, gender differences were no longer significant, but 28% of patients still reported high anxiety (BSI ≥ 0.36); 32% still reported mild-moderate depressive symptoms (PHQ ≥ 5). There were no gender differences in HRQOL over time. In separate regression models controlling for age and gender, anxiety (p = .006) and depressive symptoms (p = .004) at 3 months each significantly predicted HRQOL at 9 months.
Conclusions: For both men and women, anxiety, depressive symptoms and HRQOL improve after Htx. However, compared to men, women report higher anxiety and depressive symptoms in the first 6 months after Htx. Clinicians should monitor anxiety and depressive symptoms, especially in women, early after transplant since they are related to later HRQOL.
Author Disclosures: L. Doering: None. B. Chen: None. K. Hickey: None. D. Mancini: None. M. Deng: None. J. Kobashigawa: None. B. Drew: None.
- © 2016 by American Heart Association, Inc.