Abstract 15950: Does Left Atrial Scar Predict Atrial Fibrillation in Elderly Patients?
Background: Left atrial (LA) scar could provide a substrate for atrial fibrillation (AF). Scar can be the manifestation of an existing aging-related structural remodeling, especially in older patients. However, not all elderly patients with LA scar develop AF.
Purpose: We examined the clinical characteristics and scar prevalence in patients aged ≥ 75 years with and without AF to understand the relationship between scar and AF.
Method: Five hundred seventy one patients undergoing radio-frequency catheter ablation for AF or supraventricular tachycardia (SVT) were included in this prospective analysis and classified into 2 groups; group 1: patients with AF (n=308) and group 2: patients with diagnosis of SVT (n=263). Left atrial (LA) scarring was determined by three-Dimensional (3D) voltage mapping.
Results: Left atrial scar was detected in 172 (56%) patients in group 1 and 134 (51%) in group 2 (p=0.24). After adjusting for age and gender in multivariable logistic model, diagnosis of AF or SVT did not show any association with the incidence of scar (p=0.22). Based on the 3D mapping, 52(30%) patients had mild, 88(51%) had moderate and 32(19%) had severe scar in group 1 and mild 50(37%), moderate 67(50%), and severe in 17(13%) in group 2 (p=0.248). No difference in age, gender and distribution of comorbidities were observed between groups (Table 1).
Conclusion: Our results indicate that scar facilitates AF in predisposed subjects only and AF susceptibility may be determined by a combination of comorbidities and genetic predisposition.
Author Disclosures: S. Mohanty: None. C. Trivedi: None. C. Gianni: None. J. Burkhardt: None. J. Sanchez: None. P. Hranitzky: None. G. Gallinghouse: None. A. Al-Ahmad: None. R. Horton: None. R. Hongo: None. S. Themistoclakis: None. A. Dello Russo: None. C. Tondo: None. L. Di Biase: Speakers Bureau; Modest; Biotronik, EpiEP, Medtronic, Inc., Janssen Pharmaceuticals, Pfizer, Inc., Boston Scientific Corp.. Consultant/Advisory Board; Modest; Biosense Webster, Inc., St Jude Medical, Stereotaxis, Inc. A. Natale: Speakers Bureau; Modest; Boston Scientific Corp, Biotronik, Medtronic, Inc., Biosense Webster, Inc, St. Jude Medical. Consultant/Advisory Board; Modest; Janssen Pharmaceuticals, St. Jude Medical, Biosense Webster Inc..
- © 2016 by American Heart Association, Inc.