Abstract 15908: Association Between Global Electrical Heterogeneity and Cardiac Structure and Function in the General Population - The Atherosclerosis Risk in Communities Study
Introduction: Measures of global electrical heterogeneity (GEH), such as spatial QRS-T angle, spatial ventricular gradient magnitude (SVGmag), azimuth (SVGazi), and elevation (SVGelv), and sum absolute QRST integral (SAI QRST) reflect cardiac electrophysiological substrate associated with sudden cardiac death. The association between GEH and cardiac structure and function has not been previously described.
Hypothesis: We hypothesized that GEH on ECG is associated with echocardiographic measures of cardiac structure and function in the general population.
Methods: In the Atherosclerosis Risk in Communities study (n= 5,390; age 76 years; 42% male; 78% white) GEH ECG parameters were measured on standard 12-lead ECGs. Regression models and standardized beta coefficients assessed the association between GEH ECG parameters and echocardiographic measures of cardiac structure and function.
Results: In univariable analysis, all GEH ECG markers were significantly associated with cardiac structure (left ventricular (LV) mass index (LVMI) and LV end-diastolic volume (LVEDV)) and function (LV ejection fraction (LVEF), E/e’ and global longitudinal strain (GLS)) except for SVGmag which was only significant associated with LVEDV (Table). After multivariable adjustment for age, sex, race, BMI, coronary heart disease, heart failure, hypertension, diabetes, smoking, heart rate, and blood pressure, all GEH parameters remained independently associated with all echocardiographic makers of cardiac structure and function (Table). Beta coefficients revealed that QRS-T angle and SAI QRST were the GEH ECG markers which had the strongest association with cardiac structure and function (Table).
Conclusion: All GEH ECG parameters, except for SVGmag, were significantly associated with echocardiographic measures of cardiac structure and function.
Author Disclosures: T. Biering-Sørensen: None. J.W. Waks: None. M. Kabir: None. C.A. Henrikson: Other; Significant; St Jude, Medtronic, Boston Scientific. W.S. Post: None. E.Z. Soliman: None. A.E. Buxton: Research Grant; Significant; Medtronic research grant; not in this subject area. M.E. Josephson: None. A.M. Shah: None. S.D. Solomon: Research Grant; Significant; Novartis, Amgen. Consultant/Advisory Board; Modest; Novartis. L.G. Tereshchenko: Research Grant; Significant; Medtronic, inc, Boston Scientific. Consultant/Advisory Board; Significant; Medtronic, inc.
- © 2016 by American Heart Association, Inc.