Abstract 15742: Healthy Lifestyle and Glucagon-like Peptide-1 in Young and Healthy Adults: a Population-based Study
Aims: A healthy lifestyle is associated with a lower risk of cardiovascular events and mortality, but underlying mechanisms are not fully understood. The aim of our study was to investigate the relationships between a healthy lifestyle and glucagon-like peptide-1 (GLP-1), an incretin hormone with both glycemic and cardiovascular properties.
Methods: Healthy participants aged 25-41 years without cardiovascular disease, diabetes or a body mass index (BMI) >35 kg/m2 were enrolled in a population-based study. The following metrics were used to build a lifestyle score ranging from 0 to 7 (higher score indicating healthier lifestyle): blood pressure (BP) (<120/80 mmHg), plasma levels of glycated haemoglobin (<5.7%), total cholesterol levels (<200 mg/dl), BMI (<25 kg/m2), never smoking cigarettes, physical activity (>75 min/week) and a healthy diet.
Results: Among 2133 participants median age was 36.7 years and 53.3% were female. GLP-1 levels significantly decreased from 43.6 to 28.7 ng/l across increasing lifestyle score categories (p<0.0001). This linear relationship persisted in multivariable adjusted linear regression models (β for GLP-1 per 1-unit increase of the lifestyle score -0.06; 95% confidence intervals [-0.07, -0.04]; p<0.0001) and across lifestyle score categories (p for trend <0.0001, Figure). Individual health metrics that were significantly associated with GLP-1 were a normal BMI (-0.07; [-0.12, -0.03]; p=0.0009), low total cholesterol levels (-0.07; [-0.12, -0.03]; p=0.002), normal BP (-0.05; [-0.10, -0.01]; p=0.03) and not smoking cigarettes (-0.07; [-0.11, -0.03]; p=0.002).
Conclusions: A healthy lifestyle is strongly associated with GLP-1 levels in young and healthy adults. GLP-1 related mechanisms may therefore be involved in lifestyle related beneficial effects.
Author Disclosures: P. Krisai: None. S. Aeschbacher: None. F.J. Ruperti Repilado: None. T. Schoen: None. A. Reusser: None. M. Meier: None. J. Todd: Employment; Significant; Employee Singulex. J. Estis: Employment; Significant; Employee Singulex. M. Risch: None. L. Risch: None. D. Conen: None.
- © 2016 by American Heart Association, Inc.