Abstract 15689: Anxiety and Depression Predict 1-year Mortality in Cardiac Patients: Results From the National Denheart Survey
Introduction: Results from national DenHeart survey shows, that anxiety is present among 32% and depression among 19% of cardiac patients. Previous studies indicate that these symptoms are associated with an increased risk of mortality in patients with HF and ICD. Crucial knowledge about the danger of anxiety and depression across cardiac diagnoses is lacking.
Hypothesis: The hypothesis was that patients with anxiety or depression have a higher mortality risk. The objective was to explore if anxiety and depression is a predictor of 1-year mortality across cardiac diagnoses.
Methods: During one year all patients discharged from a national heart center were invited to participate in a health survey. The Hospital Anxiety and Depression Scale (HADS) were included and data was combined with national registers to obtain information about diagnosis at baseline and 1-year mortality. Cox regression was used to analyze anxiety and depression as predictors of mortality.
Results: In total 14,239 patients across all cardiac diagnostic groups completed the questionnaire (response rate 51%). Mean age was 64.8 (SD 12.6), 69 % male and 64 % married. Patients with HADS-A≥8 (cut-off score for anxiety) had almost twice the mortality risk compared to those with HADS-A<8 (HR 1.84 (CI 1.45-2.33)). Similarly, patients with HADS-D≥8 had more than twice the mortality risk (HR 2.36 (CI 1.85-3.00)), Table 1. Anxiety and depression predicted the largest mortality risk in patients with arrhythmia. Here, patients with HADS-A≥8 had a mortality risk almost three times as high as patients with HADS-A<8 and patients with HADS-D≥8 had more than three times the mortality risk. The same tendency was seen across all diagnostic groups except heart valve disease.
Conclusions: Cardiac patients with anxiety or depression had a higher mortality risk than patients without these symptoms, most present in patients with arrhythmia. Interventions with the aim of reducing anxiety and depression should be implemented.
Author Disclosures: S.K. Berg: None. C.B. Thorup: None. B. Borregaard: None. A.V. Christensen: None. L. Thrysøe: None. T.B. Rasmussen: None. O. Ekholm: None. K. Juel: None. M. Vamosi: None.
- © 2016 by American Heart Association, Inc.