Abstract 15680: Right Ventricular Diastolic Function in Patients With Pulmonary Hypertension Assessed by Cardiac Magnetic Resonance Imaging Derived Strain Rate Parameters: Correlation With Tau Derived From High-fidelity Micromanometer Catheter Measurement
Introduction: Right ventricular (RV) diastolic function (DF) has prognostic significance in patients with pulmonary arterial hypertension (PAH). The aim of this study was to evaluate whether cardiac magnetic resonance imaging (CMRI) derived strain rate (SR) parameters reliably reflect RV DF in PAH using tau derived from high-fidelity micromanometer catheter measurements as a gold standard
Methods: A total of 19 consecutive patients with PAH, 6 with idiopathic PAH and 13 with scleroderma-associated PAH were studied prospectively. All patients underwent right heart catheterization (RHC) and CMRI which included 4 chamber and axial cine imaging using SSFP within a few hours of each other. SR analysis of longitudinal (Figure A) and circumferential (Figure B) images were performed by Multimodality Tissue Tracking software (version 6.0 Toshiba, Tokyo, Japan). Peak systolic strain rate (SRs), peak early diastolic strain rate (SRe), peak atrial-diastolic strain rate (SRa), and deceleration time of SRe (DT) were obtained from the SR curve (Figure C). Associations between both longitudinal and circumferential SR related parameters and tau were evaluated
Results: Median age was 57 (48 - 66) years (84.2% women). Median pulmonary artery pressure, pulmonary artery wedge pressure, pulmonary vascular resistance and cardiac index, were 33 (27-49) mmHg, 9 (6 - 11) mmHg, 2.4 (2.1 - 2.6) L/min/m2, and 5.5 (4.4-9.0) W.U., respectively consistent with moderate PAH. Longitudinal SRa and DT were significantly correlated with tau (SRa: ρ = -0.63, p = .0039; DT: ρ = 0.77, p = 0.0001). Circumferential SRe, SRa and DT were also significantly correlated with tau (SRe: ρ = -0.49, p = 0.003; SRa: ρ = -0.65, p = 0.004; DT: ρ = 0.78, p = 0.0001)
Conclusions: Longitudinal and circumferential diastolic SR related parameters obtained by CMRI both detect RV diastolic dysfunction in patients with PAH. Longitudinal and circumferential DT measurements were found to have the best correlation coefficients.
Author Disclosures: T. Sato: None. B. Ambale-Venkatesh: None. J.A. Lima: None. S.L. Zimmerman: None. S. Hsu: None. R.J. Tedford: None. D.A. Kass: None. S.C. Mathai: Research Grant; Modest; the National Institutes of Health under NHLBI awards K23HL90038491. R.L. Damico: None. T.M. Kolb: None. P.M. Hassoun: Research Grant; Modest; National Institutes of Health under NHLBI awards P50 HL084946, HL114910.
- © 2016 by American Heart Association, Inc.