Abstract 15645: Plasma Trans-fatty Acids and Lipid and Lipoprotein Concentrations Among U.S. Adults: Findings From NHANES 1999-2000 and 2009-2010
Introduction: High intake of trans-fatty acids (TFAs), especially industrially-produced TFA, can lead to unfavorable lipid and lipoprotein concentrations and increased risk for cardiovascular disease. It is unknown how this relationship might change after significant reductions in TFA intake occurs in population. Our objective was to examine the association between plasma TFA levels and lipid and lipoprotein concentrations before and after the U.S. Food and Drug Administration enacted food labeling regulations for TFAs in 2006.
Hypothesis: The association between plasma TFA levels and lipid and lipoprotein concentrations will become undetectable after significant reductions in TFA intake in a population.
Methods: Data were selected from National Health and Nutrition Examination Surveys of 1999-2000 and 2009-2010. Findings on 1477 and 2348 adults, respectively, aged ≥20 years, were compared. Multivariable linear regressions were used to examine the associations between plasma TFA levels and lipid and lipoprotein concentrations. Main outcome measures were total cholesterol (TC), low-density and high-density lipoprotein cholesterol (LDL-C/HDL-C), triglyceride, and TC/HDL-C ratio.
Results: The median plasma TFA level was reduced from 80.0μmol/L in 1999-2000 to 36.9μmol/L in 2009-2010. Comparing the lowest to highest quintiles of TFA levels in 1999-2000, we found that, for example, adjusted mean LDL-C were 116.6 mg/dL (95% CI 111.8-121.3) vs 135.3 mg/dL (130.2-140.5), and HDL-C were 54.1 mg/dL (52.0-56.1) vs 44.6 mg/dL (43.0-46.3) (P<0.001). The corresponding numbers for 2009-2010 were 102.3 mg/dL (97.5-107.1) vs 128.5 mg/dL (124.5-132.8) and 56.3 mg/dL (54.6-58.1) vs 48.1 mg/dL (46.7-49.6) (P<0.001). The observed differences between the highest and lowest quintile were consistent across age groups, genders, race/ethnicities, and other covariates.
Conclusions: Despite a 54% reduction in plasma TFA levels from 1999-2000 to 2009-2010, TFA levels remained significantly associated with lipid and lipoprotein concentrations in 2009-2010. Our findings demonstrated that there was a continued significant association between plasma TFAs level and lipid and lipoprotein concentrations after significant reduction in plasma TFA levels.
Author Disclosures: Q. Yang: None. Z. Zhang: None. F. Loustalot: None. H. Vesper: None. S.P. Caudil: None. M. Ritchey: None. C. Gillespie: None. R. Merritt: None. Y. Hong: None. B.B. Bowman: None.
- © 2016 by American Heart Association, Inc.