Abstract 15565: Cerebral Microbleeds is not a Rare Observation in Patients After Cardiac Surgery : T2*-Weighted MRI Study
Background: Cerebral microbleeds (CMBs) have been described using MRI in patients with cardiovascular risk factors or cognitive dysfunction and could be an indication of small vessel disease. However, their frequency and the association of CMBs with post-cardiac surgery have not yet been studied.
Methods: In total, 76 patients were included in the current study: 38 patients who underwent cardiac surgery (mean age: 68 ± 12 years, 24 males) and 38 age- and sex-matched control subjects (mean age: 68 ± 14 years, 26 males). Brain MRI including T2 star-weighted sequences and transthoracic echocardiography were performed in these subjects. The patients with neurological abnormalities were not enrolled. CMBs were coded by researchers blind to clinical details, who independently assessed the presence and location of CMBs using a standardized form.
Results: CMBs were more prevalent in patients who underwent cardiac surgery (55%) than in control subjects (24%, P=0.009). CMBs were most frequently seen in the basal ganglia (74%), followed by the cerebral cortex (58%) among the cardiac surgery group. No significant relationship was found between CMBs and clinical conditions, including hypertension, dyslipidemia, diabetes mellitus, and smoking status. Patients with CMBs had significantly higher plasma BNP levels (median 159 pg/mL, interquartile range [IQR] 83 - 527 pg/mL) than those without (median 64 pg/mL, IQR 31 - 114 pg/mL, P < 0.001). In a multivariate logistic regression analysis, cardiac surgery (odds ratio, 3.81; 95% CI, 1.30 - 12.1; P = 0.014) and plasma BNP (odds ratio, 0.99; 95% CI, 0.99 - 1.00; P < 0.001) were parameters significantly associated with CMBs.
Conclusion: CMBs by brain MRI were found more than half of the patients who underwent cardiac surgery. Furthermore, the presence of heart failure may further increase the risk of CMBs.
Author Disclosures: Y. Yamauchi: None. Y. Kanzaki: None. Y. Wada: None. H. Shima: None. T. Katsumata: None. N. Ishizaka: None.
- © 2016 by American Heart Association, Inc.