Abstract 15556: Individuals With Familial Combined Hyperlipidemia (FCH) Exhibit Higher Arterial Wall Inflammation Compared to Familial Hypercholesterolemia (hFH). Insights From a Pilot FDG.PET Study
Introduction: Familial hyperlipidemia (FH) of either heterozygous (hFH) or combined (FCH) type is the most common atherogenic disorder of lipid metabolism leading to accelerated atherogenesis and increased cardiovascular risk. However, it is unknown whether the arterial inflammatory activation differs between these two dyslipidemias.
Hypothesis: As recent evidence indicates that arterial activity on fluorodeoxyglycose Positron Emission Tomography (FDG-PET) has a predictive role for future cardiovascular events, the aim of this pilot study was to determine if there are differences of arterial FDG-PET measurements between a) FH individuals and healthy subjects and b) hFH and FCH patients.
Methods: Twenty patients (6 female) with hFH (n=10) or FCH(n=10) with no difference in terms of age, blood glucose levels, smoking, hypertension or family history of cardiovascular disease and free of statin therapy for at least 6 months, and 13 non dyslipidaemic patients (4 female) of similar age were included. FDG uptake was evaluated in the wall of the ascending aorta (AA) in axial slices every 5mm as target-to blood ratio (TBR) by dividing SUVmax with the superior vena cava blood mean SUV to correct the arterial FDG uptake for blood pool activity. Lipid profile was obtained in all FH patients.
Results: Patients with FH had higher TBR values in AA compared to controls (p<0.001) and FCH patients exhibited higher TBR values compared to those with hFH (2.3±0.2 vs. 2±0.3, p=0.03). Total cholesterol and low density lipoprotein (LDL) values were higher in hFH patients (338±43 vs. 282±46 mg/dL, p<0.01 and 249±41 vs. 175±29 mg/dL, p=0.001, respectively), but triglyceride levels were higher (347 ±172 vs. 108 ±33 mg/dL, p=0.002) in FCH patients.
Conclusions: Increased vascular inflammation as assessed by FDG PET/CT imaging was observed in FH patients. In particular, FCH patients were characterized by higher arterial wall inflammation compared with hFH, indicating that such patients are at an even higher risk for premature cardiovascular events.
Author Disclosures: I. Koutagiar: None. K. Toutouzas: None. J. Skoumas: None. G. Benetos: None. S. Galanakos: None. R. Kotronias: None. A. Georgakopoulos: None. N. Piannou: None. P. Kafouris: None. C. Anagnostopoulos: None. D. Tousoulis: None.
- © 2016 by American Heart Association, Inc.