Abstract 15526: Dietary Fat Quantity and Quality Modifies Advanced Glycation End Products Metabolism in Patients With Metabolic Syndrome
Introduction: Metabolic Syndrome (MetS) is considered a major cause of cardiovascular and other chronic diseases. Advanced glycation end products (AGEs) increase in dysmetabolic conditions. Lifestyle, including diet, has shown be effective in preventing the development of MetS.
Hypothesis: We investigated whether AGEs metabolism is affected by diets with different fat quantity and quality in MetS patients.
Methods: Seventy-five patients from LIPGENE cohort were randomly assigned to one of four diets: high saturated fatty acids (HSFA); high monounsaturated fatty acids (HMUFA) and two low-fat, high complex carbohydrate diets, with or without supplemented with long-chain n-3 polyunsaturated fatty acids (LFHCC n-3 and LFHCC), for 12 weeks each. Total dietary AGEs consumed, serum AGEs [methylglyoxal (MG) and N-carboxymethyllysine (CML) levels and AGER1, RAGE, GloxI and Sirt1 mRNA levels were determined after a 12-hour fast and 4 hours after a test meal at the end of the intervention.
Results: HMUFA diet had the lowest and HSFA provided the highest levels of dietary AGEs with an intermediate effect for LFHCC and LFHCC n-3 diets. Fasting and postprandial serum AGEs and mRNA levels of AGER1, GloxI and Sirt1 were lower after HMUFA diet and higher after HSFA diet and were intermediate after both LFHCC and LFHCC n-3 diets (all p < 0.05). Multiple regression analyses showed that sMG and AGER1 mRNA appeared as significant predictors of parameters related to oxidative stress and inflammation.
Conclusions: The low AGEs content in HMUFA diet reduces circulating AGEs and modulates the gene expression related to AGEs metabolism in MetS patients, which may be used as a therapeutic approach to reduce the incidence of MetS and related chronic diseases.
Author Disclosures: J. Lopez-Moreno: None. A. Garcia-Rios: None. G.M. Quintana-Navarro: None. A. Camargo: None. F. Gomez-Delgado: None. A.I. Perez-Caballero: None. P. Perez-Martinez: None. J. Lopez-Miranda: None. E.M. Yubero-Serrano: None.
- © 2016 by American Heart Association, Inc.