Abstract 15408: Elevated Plasma Tgf-β1 Levels Predicted the Development of Hypertension in Normotensives in a General Population: The 14-Year Follow-Up Study in Uku Town
Introduction: Transforming growth factor β1 (TGF-β1) is a multifunctional cytokine. There is evidence that TGF-β1 is involved in the pathogenesis of hypertension and the development of hypertensive target organ damage. Several studies have shown that TGF-β1 induced vascular hypertrophy and remodelling in various vascular diseases. However, there are no reliable data on hypertension in the epidemiological studies.
Hypothesis: The present study tested the hypothesis whether elevated TGF-β1 levels predict the development of hypertension.
Methods: In 2002-2004, a total of 528 subjects received a health examination in a fishing community in southwestern Japan (Uku town). We examined blood pressure, body mass index (BMI) and blood chemistries. Data on fasting plasma TGF-β1 were obtained from 528 individuals. Of these, 149 normotensives (blood pressure <140/90 mmHg without anti-hypertensive medications) at baseline were followed-up for 14 years. The ROC curve was used to identify the maximum of sensitivity and specificity. The calculated cut-off value was 8.9ng/ml.
Results: Of 149 normotensives at baseline, 59 subjects developed hypertension. Plasma TGF-β1 levels were significantly associated with the development of hypertension after adjustment for confounding factors. In order to further examine the association between TGF-β1 levels and the development of hypertension, we performed logistic regression analysis. We divided the baseline plasma TGF-β1 levels into two groups using a cut-off value. The significant high odds ratio [4.509 (95% CI, 1.416-14.358)] for the development of hypertension was found in the highest group of plasma TGF-β1 level vs. the lowest group after adjustment for confounders.
Conclusions: This is the first report demonstrating the causal relationship between elevated TGF-β1 and the development of hypertension. Elevated plasma TGF-β1 levels predicted the development of hypertension in normotensives in a population of community-dwelling Japanese.
Author Disclosures: E. Nakao: None. H. Adachi: None. M. Enomoto: None. A. Fukami: None. E. Kumagai: None. S. Nakamura: None. A. Obuchi: None. Y. Nohara: None. N. Morikawa: None. S. Kono: None. A. Sakaue: None. T. Tsuru: None. Y. Fukumoto: None.
- © 2016 by American Heart Association, Inc.