Abstract 15386: The Recurrence of Atrial Fibrillation Was Associated With High Oxidative Stress in Coronary Sinus Vein
Mechanisms of oxidative stress associated with the recurrence of Pulmonary vein atrium isolation (PVI) remain unclear. Therefore, we investigated oxidative stress levels on atrium , and coronary sinus vein (CS) and artery (A) in patients with paroxysmal AF (PAF) and persistent AF (PSAF) and estimated the relationship between LA pressure levels and the predictors of recurrence after ablation.
Methods: 80 patients who underwent radiofrequency catheter ablation(RFCA) for AF in Shinshu Univ Hospital from 2014 to 2016 were enrolled.(60.3±7.4 yrs, 72 male,PAF : n = 32, PSAF : n = 48).We obtained blood samples from (A) and left (LA) and right atrium (RA) and (CS) at RFCA to evaluate oxidative stress level by measuring Diacron-reactive oxygen metabolite (dROM). Left atrium pressure was also measured.
Result: The CS-dROM were higher than any other sites in both PAF and PSAF patients and the CS-dROM levels in PSAF patients were higher than those in PAF patients. ( PSAF: 586.4±82.9 U.Carr, p<0.001). The CS-dROM levels showed a significant correlation with left atrial mean pressure levels in PSAF patients. (r = 0.629, p < 0.001 , respectively). After procedual outcome, LA pressure and Left atrium volume index(LAVI) were not corrected clinical recurrence after ablation. (P=0.832) The CS-dROM levels in recurrence of af were significantry higher than in patients with no recurrence. (750±60.3 U.Carr vs 550±100 U.Carr, p<0.001)
Conclusions: Our PVI could achieve SR maintenance in almost 80% during 6months followup. The preprocedural oxidative stress in coronary sinus vein was an important predictor of the procedural outcome.
Author Disclosures: A. Okada: None. M. Shoda: None. K. Kato: None. T. Takeuchi: None.
- © 2016 by American Heart Association, Inc.