Abstract 15351: Association of Life’s Simple 7 and Non-Alcoholic Fatty Liver Disease: The Multi-Ethnic Study of Atherosclerosis
The AHA defined life’s simple 7 (LS7) as a measure of Cardiovascular health (CVH). Non-alcoholic fatty liver disease (NAFLD) is considered a significant risk factor for increased CVD. We evaluated the association between LS7 and NAFLD.
Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) cohort enrolled 6814 adults without prior CVD. We excluded 2,913 participants who had missing variables or increased risk for chronic liver disease at baseline. The LS7 health score was calculated by adding the score of each of the 7 metrics (blood pressure, cholesterol, BMI, smoking, glucose, diet and physical activity) for a total of 14. Two points for ideal, 1 point for intermediate, and 0 point for poor. In total, 0-8 was considered poor, 9-10 intermediate, and 11-14, ideal. NAFLD was defined using non-contrast cardiac CT and a liver/spleen attenuation ratio (L/S) < 1. Multivariate robust linear and logistic regression analyses were performed to evaluate the association.
Results: Our cross-sectional analysis of 3,901 participants showed 19% (n=747) had ideal CVH score, 33% (n=1,270) intermediate CVH score and 48% (n=1,884) had a poor CVH score. The overall prevalence of NAFLD was 18% with a distribution of 7%, 14%, and 25% in the ideal, intermediate, and poor LS7 groups, respectively (p<0.001).White participants were most likely to have an ideal CVH score (51% n=378) while the African American group was the least prevalent in this group, 16% (n=120), p <0.001. From an adjusted model, individuals in the intermediate and poor LS7 groups had higher NAFLD prevalence compared to individuals with ideal LS7 score: odds ratio (OR) for intermediate group 1.84 (95% CI 1.32-2.55), p<0.001; Poor OR 3.06 (95% CI 2.21-4.22),p<0.001.
Conclusion: There is an association between LS7 and NAFLD. More optimal CVH scores are associated with a lower NAFLD prevalence. This study builds on prior studies that shows that CVH is related to other outcomes and LS7 could be a target for prevention of Liver disease.
- Cardiovascular health
- Life’s Simple 7/My Life Check
- Physical activity and exercise
- Cardiovascular disease
Author Disclosures: E.T. Oni: None. O. Ogunmoroti: None. N. Allen: None. R. Blankstein: None. S.S. Martin: None. M. Cushman: None. P.H. Joshi: None. M.J. Budoff: None. M.J. Blaha: None. R.S. Blumenthal: None. E. Veledar: None. K. Nasir: None.
- © 2016 by American Heart Association, Inc.