Abstract 15315: Clinical Risk Factors for Onset of Atrial Fibrillation Early After Acute Myocardial Infarction
Introduction: Atrial fibrillation (AF) occurring early after acute myocardial infarction (AMI) is as an independent predictor of adverse short- and long-term outcomes. Risk factors for AF include advancing age, male sex, diabetes mellitus, hypertension, presence of chronic kidney disease, and elevated inflammatory marker concentrations. It is not well elucidated whether these factors are also associated with occurrence of AF early after AMI. We investigated the predictors for AF among clinical factors in patients with AMI.
Methods: The study population was consisted of consecutive 495 patients with AMI (65±13 years old, 79.6% male) who did not show AF at hospital admission. We observed the AF occurrence during hospital stay, and compared clinical characteristics between patients with and without AF. We determined the factors associated with AF using univariate and multivariate analysis. We also followed the study patients (median: 1242 days) to determine the long-term all-cause mortality.
Results: AF occurred during hospital stay in 72 out of 495 patients (14.5%), and they had longer hospital stay than those without it (28±33 vs. 37±31 days, p=0.04). Kaplan-Meier survival curve analysis demonstrated that patients with AF had higher mortality than those without it over the follow-up period (p<0.0001 by logrank test). Patients with AF was significant older than those without it (64±12 vs. 69±13 year old, p=0.04) while there were no differences in gender, site of infarction (anterior wall or not), prevalence of coronary factors, estimated GFR, and body mass index. They had higher peal CK (3093± 3431 vs. 4360±4410 IU/L, p=0.006) and high-sensitive CRP on admission (16.0±36.0 vs. 27.8± 58.2 mg/L, p=0.047) than those without AF. Multivariate logistic regression analysis selected age, peak CK and high-sensitive CRP as independent predictors for new onset AF.
Conclusions: AF occurrence early after AMI is associated not only with older age and larger infarct size but also with elevated inflammatory marker concentration among general risk factors of AF.
Author Disclosures: K. Iwakura: None. A. Okamura: None. Y. Koyama: None. K. Inoue: None. M. Iwamoto: None. H. Nagai: None. Y. Toyoshima: None. K. Tanaka: None. T. Oka: None. K. Fujii: None.
- © 2016 by American Heart Association, Inc.