Abstract 15263: Higher Left Atrial Systolic Force is Associated With Insulin Resistance, Dyslipidemia, and Cardiac Hypertrophy in Obese Children
Background: Obesity is associated with left atrial (LA) enlargement, but there is little information about LA functional change in children. The purpose of the study is to assess the relationship between LA systolic force and cardiometabolic risk factors in obese children.
Methods: Echocardiography with tissue Doppler imaging was performed in 395 children aged 7 to 15 years. LA diameter, LV end-diastolic volume, ejection fraction (EF), mass, and mass-to-volume ratio were measured. Transmitral peak flow velocities during early and late diastole and mitral annular myocardial velocities during early (Em) and late diastole (Am) were measured. Tissue Doppler-derived LA systolic force and myocardial performance index (MPI) were assessed. Lipids, uric acid, and, homeostasis model assessment for insulin resistance (HOMA-IR) were also assessed. Subjects were divided into 4 groups: A group, waist circumference (WC) within normal range; B group, increased WC; C group, increased WC plus any one of the following individual factors of hypertension, dyslipidemia (low high-density lipoprotein-cholesterol and/or high triglyceride), and raised fasting glucose; D group, metabolic syndrome.
Results: There were significant relationships between LA systolic force and body mass index, systolic blood pressure, LA diameter, M/V ratio, and MPI (0.28, 0.34, 0.42, 0.29, and 0.18, respectively, p < 0.01). LA systolic force correlated significantly with HOMA-IR, triglycerides, and uric acid (r = 0.21, 0.23, and 0.20, respectively, p < 0.01). With increasing number of metabolic syndrome disorders, LA systolic force increased significantly from group A to group D (Figure).
Conclusion: Higher LA systolic force is associated with insulin resistance, dyslipidemia, hyperuricemia, and concentric LV hypertrophy. LA functional change becomes apparent with increasing number of metabolic syndrome disorders.
Author Disclosures: K. Harada: None. Y. Harada: None. M. Toyono: None.
- © 2016 by American Heart Association, Inc.