Abstract 15073: High Sensitivity C Reactive Protein is Associated With Carotid Intoma Media Thickness in White but Not Black Individuals. The Brazilian Longitudinal Study of Adult Health (ELSA Brasil)
Introduction: Carotid intima media thickness (cIMT) differences across races are insufficiently explained by traditional cardiovascular risk factors distribution
Hypothesis: hsCRP association with cIMT vary between individuals of white, black and mixed races
Methods: We addressed cross-sectional association of hsCRP with cIMT in 8603 individuals free of cardiovascular/chronic inflammatory disease and not taking statins at baseline ELSA-Brasil. hsCRP was measured by imuno chemiluminescence and cIMT by standard ultrasound method in common carotid artery. Increase in cIMT was estimated per one standard deviation (SD) increase in log hsCRP using linear regression in separate models for white, black and mixed participants. Confounders were demographics, lifestyle characteristics, family CAD history and waist circumference. We further adjusted the model for hypertension, dyslipidemia and diabetes diagnoses
Results: Blacks had higher hsCRP (1.64 [0.80-3.80] vs 1.37 [0.70 - 3.10], p value <.001) and higher cIMT (respectively, 0.595 [0.530 - 0.690] vs 0.570 [0.505 - 0.660], p value <.001) than white individuals. In addition, blacks were more obese, sedentary, had more prevalent tabagism, diabetes, hypertension and dyslipidemia compared to white individuals. Individuals of mixed race had intermediary profile. In blacks hsCRP levels were not associated with cIMT (0.003 per SD [95%CI -0.005, 0.010])(figure). By contrast, hsCRP was associated with cIMT in whites (0.006 per SD [0.003, 0.009]) and individuals of mixed race (0.005 per SD [0.000, 0.010]) in models controlled for demographics, lifestyle characteristics, family CAD history and waist circumference. In fully-adjusted models, hsCRP remained significantly associated with cIMT in whites (0.004 per SD [95%CI 0.001, 0.007])
Conclusions: hsCRP is associated with cIMT in whites, but not in black individuals. The role of inflammation over cIMT is heterogeneous across races and should be further explored
Author Disclosures: P.H. Harada: None. I.S. Santos: None. T. Rundek: None. I.M. Benseñor: None. P.A. Lotufo: None.
- © 2016 by American Heart Association, Inc.