Abstract 15009: Assessment of Myocardial Adaptation by Speckle Tracking Echocardiography and Clinical Outcome After Isolated Mitral Surgery in Patients With Chronic Mitral Regurgitation
Introduction: The risk of left ventricular (LV) functional maladaptation after surgery for isolated MR is poorly defined. We aimed to evaluate LV contractile function using two-dimensional global speckle-tracking (2D GLS) analysis and the clinical status of patients with isolated mitral regurgitation (MR) after surgery.
Hypothesis: Following surgery for isolated mitral valve regurgitation, left ventricular function is optimized as confirmed by Simpson method and speckle tracking.
Methods: A cohort of 137 patients with significant MR undergoing mitral valve repair between July 2014 and May 2015 were prospectively enrolled. Serial echocardiographic studies were performed before surgery, 7 days after surgery and at least 3 months postoperatively.
Results: Mean age of patients was 65.8±12.7 years and 66 of them (48.2%) were male. Mean Euro Score I was 8.6 ± 8.5 %. Mean LV EF decreased from 57.4 ± 11.7% to 49.8 ± 11.2% (p<0.001), the GLS deteriorated from -19.2 ± 4.1 % to % -15.7 ± 3.8% (p<0.001) and the time dispersion increased from 88.3 ± 11.6 to 117.4 ± 115.2 msec (0.004). Nevertheless, there was a signifincant improvement of NYHA classification from 2.8 ± 0.6 to 1.9 ± 0.6 (p<0.001) and of 6-min walking test from 372.31 ± 31.6 m to 424.8 ± 117 m (p<0.001). Thirty-day mortality was 2.2 % (n=3).
Conclusions: After isolated mitral valve repair the increase of LV afterload leads to a deterioration of the LV contractile function and at the same time resulting in an improvement of the clinical status.
Author Disclosures: Z. Dimitriadis: None. T. Pühler: None. O. Oldenburg: None. H. Omran: None. L.K. Wolf: None. L. Paluszkiewicz: None. K. Hakim-Meibodi: None. C. Piper: None. D. Horstkotte: None. J. Gummert: None. L. Faber: None.
- © 2016 by American Heart Association, Inc.