Abstract 14997: Increase in Cerebral Oxygenation During Pre-Hospital Cpr is Associated With Rosc, a Multicenter Study
Introduction: During pre-hospital CPR monitoring possibilities are limited. In particular specific and reliable information about the brain is absent during CPR leaving physicians unaware of the efficiency of his CPR efforts on cerebral perfusion and ensuing ischemic organ damage.
Hypothesis: We assessed whether higher regional saturation (rSO2) and/or higher increase in rSO2 is associated with ROSC. Material and methods With IRB approval we prospectively measured rSO2 (Nonin Medical) during ALS in consecutive OHCA patients in six medical centers in Belgium. One sensor was applied on the right side of patient’s forehead when the emergency team arrived in an OHCA setting. Monitoring was continued until the patient arrived at the ICU or resuscitation was discontinued. ROSC was defined as ROSC > 20 min.
Results: We included 331 patients of which 112 achieved ROSC. The overall mean rSO2 until 2min before ROSC was significantly higher in the group who achieved ROSC (41±13) versus no-ROSC (33±13; p<0.001). The gradual increase from initial rSO2 until 2min before ROSC or the end of ALS efforts, was significantly larger in the group with ROSC (17% (5-28) compared to the no-ROSC group (8% (2-13); p < 0.001). Also the first measured rSO2 value and mean rSO2 of the first min was significantly higher in the patients who achieved ROSC, respectively 30±18 versus 24±14 (p=0.005) and 33±17 versus 28±14 (p = 0.004).
Conclusion: This study demonstrated that rSO2 might determine whether OHCA patients will achieve ROSC. Patients who experienced ROSC had a steeper increase in rSO2, a higher overall and initial rSO2 and a mean of the first min rSO2 significantly larger as compared to patients who did not achieve ROSC.
Author Disclosures: C. Genbrugge: None. W. Eertmans: None. F. Jans: None. W. Boer: None. C. De Deyne: None.
- © 2016 by American Heart Association, Inc.