Abstract 14867: Depression is a Major Predictor of Quality of Life in Adults Supported by a Left Ventricular Assist Device
Introduction: Anxiety and depression are prevalent in heart failure (HF). However, very little is known about the associations among anxiety, depression, and quality of life (QOL) in advanced HF patients living with a left ventricular assist device (LVAD). The purpose of this study was to examine the relationships among anxiety, depression, and QOL, and to determine the extent to which anxiety or depression predict QOL outcomes.
Methods: Adults supported by LVAD in this cross-sectional, observational study were recruited from 2 on-line LVAD support groups. Each participant completed a demographic questionnaire, NIH-PROMIS Short Form measures of anxiety (8 items) and depression (8 items), and the World Health Organization QOL-BREF Questionnaire (26 items) including 4 domains of QOL: physical, psychological, social, and environmental. Descriptive and inferential statistics procedures were used for data analyses.
Results: Adults living with LVADs (N = 102) for an average implant duration of 18.5 ± 15.1 months completed the study. The majority of the study participants were white (77%), male (70%) and 20 to 80 years old (mean=51.9±13.3 years). Anxiety and depression were negatively associated with QOL (global and all domains). Pearson’s correlation coefficients ranged from r = -0.43 to r = -0.78 (p < 0.0001). Multivariate regression analyses showed that anxiety and depression were significant predictors of global QOL (Adj. R2 =0.46, p <.0001). Furthermore, results of regression analysis showed that when depression was increased by 1 standard deviation, the domains of QOL decreased by 0.30 (physical), 0.55 (psychological), 0.32 (social), and 0.51 (environmental) units assuming anxiety was held constant (p <.0001).
Conclusions: The data inferred that higher levels of anxiety and depression are associated with lower QOL. However, depression most consistently predicted QOL in adults living with LVADs. Longitudinal studies are warranted to further understand the mechanism and effect of depression on all domains of QOL crucial for optimizing LVAD therapeutic outcomes.
Author Disclosures: M. Abshire: None. H. Wu: None. J. Casida: None.
- © 2016 by American Heart Association, Inc.