Abstract 14863: Iron Overload May be a Novel Risk Factor for Long-term Progression of Coronary Atherosclerosis
Background: Iron deficiency is reported to be associated with poor quality of life, impaired exercise tolerance, and mortality independent of hematopoietic effects in the patient with heart failure. On the other hand, it has been reported that iron overload may be correlated with hypertension and arteriosclerosis but the long-term effect of iron overload as cardiovascular risk is unknown. In this study, we investigated the long- term effects of iron overload on coronary atherosclerosis.
Methods: We enrolled 90 patients with coronary atherosclerosis who had been diagnosed by coronary angiography or had undergone percutaneous coronary intervention in 2007 and were followed until 2015. We compared the incidence of coronary risk factors including hypertension, dyslipidemia, diabetes mellitus, smoking and chronic kidney disease and iron sufficiency between the progression group who showed progression of coronary artery disease (new finding of >75% stenosis or receiving percutaneous coronary intervention) during 8-year follow-up and the non-progression group who did not show the change of coronary atherosclerosis. Iron overload was defined as transferrin saturation >20% and ferritin level >100μg/L using blood sample in 2007.
Results: The progression group consisted of 48 patients and the non-progression group consisted of 42 patients. The incidence of iron overload of the progression group was significantly higher than that of the non-progression group (52% vs. 29%, p=0.032) while there were no significant differences of the other factors between the two groups. Kaplan-Meier curve indicated that the progression of coronary atherosclerosis was significantly higher in the patients with iron overload (n=37) than those with non iron overload (n=53) during 8 years (p=0.041) (figure).
Conclusion: Iron overload can become a novel risk factor for long-term progression of coronary atherosclerosis.
Author Disclosures: K. Yasumura: None. M. Nishino: None. N. Okamoto: None. A. Tanaka: None. N. Mori: None. D. Nakamura: None. M. Yano: None. N. Makino: None. Y. Egami: None. R. Shutta: None. J. Tanouchi: None.
- © 2016 by American Heart Association, Inc.