Abstract 14837: Reduced Functional Capacity: An Independent Risk Predictor of Atrial Fibrillation
Introduction: Atrial fibrillation (AF) affects up to 20% of pts over the age of 80 in the community. AF is associated with significant impairment of functional capacity and quality of life (QoL), but the presence of these features prior to the onset of AF is undefined.
Aim: To investigate if poor functional capacity and QoL are independently associated with AF risk in pts with risk factors.
Methods: In a community-based study, pts ≥65 years were recruited if they had ≥1 risk factor (mainly hypertension, diabetes mellitus, obesity). Baseline echocardiography and functional capacity was assessed using a combination of six minute walk test (SMWT), the Duke Activity Status Index (DASI), Minnesota Living with Heart Failure score (MLHF), Charlson Index and EuroQoL5D Visual Analog Scale (EQ-VAS). Patients were split into four groups based on the CHARGE-AF score (low risk 0-5%, medium 5-10%, high 10-15% and very high >15%). Functional capacity and QoL were compared with clinical AF risk using simple and multivariable linear regression. Receiver Operator Characteristics (ROC) curves were used to assess for independent risk factors for AF.
Results: 607 pts (71±5 y, 47% men) were split into 4 groups based on AF risk. Patients in the higher AF risk groups were older and had increased rates of hypertension, diabetes mellitus and ischaemic heart disease (p < 0.05). Higher AF risk was associated with male gender with lower mean six minute walk test, DASI and higher mean MLHF and Charlson Index (p < 0.05). Simple linear regression showed the same parameters were potential predictors of clinical AF risk (p < 0.05). ROC curves showed SMWT < 500m (AUC 0.60, p < 0.001), DASI < 42.7 (AUC 0.64, p < 0.001) and MLHF > 24 (AUC 0.594, p = 0.022) were associated with AF risk. SMWT was found to be an independent marker of clinical AF risk using multivariable linear regression (Table).
Conclusion: As well as being associated with AF, poor functional status and QoL are independently associated with AF risk.
Author Disclosures: S. Ramkumar: None. H. Yang: None. Y. Wang: None. M. Nolan: None. K. Negishi: None. T.H. Marwick: None.
- © 2016 by American Heart Association, Inc.