Abstract 14835: Association of Underweight With Prognosis in Patients With Peripheral Artery Disease; From IMPACT-ABI Registry
Introduction: Generally, it is reported that being underweight is associated with higher mortality. However, little is known about association of underweight with prognosis in patients with peripheral artery disease (PAD).
Methods: IMPACT-ABI registry was a retrospective, single-center study enrolled 3131 patients who were hospitalized for cardiovascular disease and measured by ABI between January 2005 and December 2012. From this registry, we identified 512 PAD patients whose ABI was less than 0.90 or who had received revascularization therapy of the lower limbs, and divided into two groups according to body mass index (BMI); underweight group (BMI <18.5) (n=56), non-underweight group (BMI ≥18.5) (n=456). The primary end point was all-cause death.
Results: The mean follow-up period was 1195.0 ± 471.7 days. Underweight group had frequently hypertension, old myocardial infarction, lower ABI, hemoglobin, serum triglyceride and HbA1C levels and higher HDL cholesterol and BNP levels in comparison with non-underweight group. The all-cause mortality rate was remarkably higher in the underweight group than in the non-underweight group (60.9% vs 23.1%, p<0.001), and the cardiovascular death rate was also significantly higher in the underweight group (29.7% vs 7.1%, p<0.001) among PAD patients. In multivariate Cox analysis, mortality was significantly associated with underweight, age, old cerebral infarction, hemodialysis, heart failure, serum albumin and CRP levels. Underweight was strong predictor for all-cause mortality (HR: 2.90; 95%CI: 1.73-4.86, p<0.001)
Conclusions: The incidence of mortality was significantly higher in underweight patients with peripheral artery disease especially.
Author Disclosures: K. Senda: None. T. Miura: None. T. Mochidome: None. Y. Ueki: None. T. Saigusa: None. S. Ebisawa: None. H. Motoki: None. J. Koyama: None.
- © 2016 by American Heart Association, Inc.