Abstract 14771: High Burden of Ventricular Premature Complex in Addition to Age and Diastolic Dysfunction are Correlated With Recovery of Neurohormonal Cardiac Dysfunction After Ablation
Background: Frequent premature ventricular complexes (PVC) occasionally cause cardiomyopathy and, in some cases, cardiac dysfunction can recover after catheter ablation for PVC. The pathophysiology of these cardiomyopathies remains unknown, but hypotheses mainly include ventricular dyssynchrony resulting in hemodynamic disturbances and abnormalities in calcium handling and oxygen consumption.However, there are few reports on recovery of neurohormonal dysfunction after ablation for frequent PVC
Aim: In this study, we investigated which factors were correlated with the recovery of neurohormonal cardiac dysfunction after ablation for PVC
Methods: We enrolled the consecutive patients who underwent successful ablation for frequent PVC. We divided our patients into the two group: the recovery (R) group whose brain natriuretic peptide (BNP) were decreased more than 50pg/ml after ablation as compared to the value before ablation and non-recovery (NR) group whose BNP were decreased less than 50pg/ml after ablation. We compared age, gender, BNP values before and after ablation, echocardiographic parameters including ejection fraction (EF), ratio of early (E) to late (A) ventricular filling velocities (E/A ratio), deceleration time (DcT), electrophysiologic parameters including PVC burden determined by Holter ECG, PVC duration, coupling time and origin between the two groups.
Results: Age, DcT and PVC burden were significantly larger and E/A was significantly lower in R group (n=11) than in NR group (n=13). In addition, the clinical PVC QRS duration and the incidence of epicardium origin showed a higher tendency in R group as compared to NR group.
Conclusions: PVC burden in addition to age and diastolic dysfunction are associated with recovery of neurohormonal cardiac dysfunction after ablation. Ablation for frequent PVC may be recommended for older patients with diastolic cardiac dysfunction who have high burden of PVC.
Author Disclosures: N. Makino: None. Y. Egami: None. A. Tanaka: None. N. Okamoto: None. N. Mori: None. D. Nakamura: None. M. Yano: None. R. Shutta: None. M. Nishino: None. J. Tanouchi: None.
- © 2016 by American Heart Association, Inc.