Abstract 14731: Sinus Node Recovery Time and Minor Allele of ZFHX3 SNP Were Independent Predictors of Atrial Fibrillation Recurrence After Pulmonary Vein Isolation
Background: The AF related SNPs have been reported to be associated with the outcomes after AF ablation, but it remains controversial. We investigated the predictors of paroxysmal AF (PAF) recurrence after pulmonary vein isolation (PVI) using clinical and genetic parameters.
Methods: We investigated the association between the PAF and the GWAS reported SNPs (KCNN3, PRRX1, CAV1, C9orf3, HCN4, ZFHX3, PITX2, SYNE2 and SYNPO2L), using 344 Japanese PAF patients hospitalized in Hiroshima University hospital and 1,507 healthy controls. The SNPs of PRRX1 (rs3903239), ZFHX3 (rs2106261), and PITX2 (rs6817105) were associated with PAF (minor allele frequencies (MAF) PAF vs control=58.1%vs53%, OR 1.24, P=1.9х10-2, 39.8%vs30.2%, OR 1.52, P=1.6х10-6, 64.7vs47.3%, OR 2.0 P=3.71х10-16, respectively). We divided the PAF patients followed more than 12 month after PVI (N=250) into recurrence (N=41) and non-recurrence (N=209) groups. We compared age, sex, BMI, durations of AF, left atrial diameter, ejection fraction, left atrial volume, corrected sinus node recovery time (CSRT), AH time, HV time, rate of hypertension, diabetes, thyroid diseases, ischemic heart disease, and apnea hypopnea index, and the MAF rates of the 3 associated SNPs in the both groups.
Results: Multivariate analysis revealed that the CSRT was longer (522±280ms vs440±204ms OR 1.3 P=0.018) and the MAF rate of ZFHX3(rs2106261) was lower (31.7%vs41.9% OR 1.2 P=0.035) in recurrence group than non-recurrence group.
Conclusion: We replicated the AF related GWAS SNPs and the PRRX1, ZFHX3, and PITX2 SNPs were associated with PAF. We found that the PAF patients with longer sinus node recovery time were easily to recur and those with minor allele of ZFHX3 SNP were less likely recur. These results were meaningful to thinking about a pathology of AF and decide a strategy of AF treatment strategy.
Author Disclosures: S. Tomomori: None. Y. Nakano: None. T. Tokuyama: None. A. Sairaku: None. H. Matsumura: None. M. Amioka: None. N. Hironobe: None. Y. Kihara: None.
- © 2016 by American Heart Association, Inc.