Abstract 14578: Impact of Cystatin C and Microalbuminuria on Cognitive Impairment in the Population of Community-dwelling Japanese
Introduction: Cognitive impairment is an important element, which prescribes our healthy life, and the evaluation is an urgent task in the modern society. But it is difficult to estimate the early detection of that using a simple biomarker. Recent studies have shown that the kidney dysfunction might be undermined by the cognitive impairment. However, nobody knows which biomarkers of the renal dysfunction would predict the cognitive impairment.
Hypothesis: To investigate whether cystatin C and microalbuminuria, sensitive biomarkers of the early renal dysfunction, may predictable parameters for the cognitive impairment.
Methods: A total of 1,943 subjects (774 males, 1,169 females, mean age 65.8±11.3 years) were enrolled in Tanushimaru, Japan in 2009. The cognitive function was evaluated by using mini-mental state examination (MMSE). We defined less than 24 of MMSE scores as the cognitive impairment. We measured serum cystatin C using latex nephelometric immunoassay. Spot urine samples were used to measure microalbuminuria levels. All statistical analyses were performed using SAS system.
Results: The mean levels of log-transformed cystatin C were 0.95 (range 0.4-7.1) mg/l, and log-transformed microalbuminuria levels were 11.0 (range 1.1-2600) mg/g.Cr. The means of MMSE score were 27.6±2.5. In the multivariate linear regression analyses adjusted for age and sex, MMSE was significantly associated with systolic blood pressure (p=0.024, inversely), cystatin C (p=0.046, inversely) and microalbuminuria (p=0.019, inversely), whereas, eGFR was not significant (p=0.20). After adjustment for systolic blood pressure in addition to age and sex, the significance of cystatin C was still remained (p=0.049, inversely). In the multiple logistic regression analyses adjusted for age and gender, the significance of microalbuminuria with MMSE was still remained (odds ratio: 1.23; 95%CI: 1.035-1.463; p=0.019).
Conclusions: We demonstrated for the first time that the cognitive function was significantly and inversely associated with cystatin C and microalbuminuria rather than eGFR in the general population. It may be needed to examine the causal relationship between the cognitive dysfunction and cystatin C or microalbuminuria in a longitudinal survey.
Author Disclosures: S. Kono: None. H. Adachi: None. M. Enomoto: None. A. Fukami: None. E. Kumagai: None. S. Nakamura: None. Y. Nohara: None. N. Morikawa: None. E. Nakao: None. A. Sakaue: None. T. Tsuru: None. Y. Fukumoto: None.
- © 2016 by American Heart Association, Inc.