Abstract 14571: Short Telomere Length is a Marker of Renal Aging in a Japanese Cohort
Introduction: Short telomere length has been shown to be associated with atherosclerotic change and cardiovascular damage, in studies of primarily Western populations.
Hypothesis: We tested the hypothesis that leukocyte telomere length is associated with cardiovascular and renal target organ damage in a Japanese cohort, in which life expectancy is very high.
Methods: We enrolled 770 subjects who have at least one cardiovascular risk factor. We measured leukocyte telomere length by quantitative PCR (T/S ratio), and measured other biomarkers from blood and urine samples. We also assessed flow-mediated vasodilation (FMD), pulse wave velocity (PWV), carotid artery augmentation index (CAAI), and urinary albumin creatinine ratio (UACR) as surrogate markers of arterial stiffness and cardiovascular organ damage.
Results: The mean age was 59.5±12.2 years; 58.0% were male; and the mean BMI was 25.1±4.6 kg/m2. T/S ratio was inversely associated with age (r=-0.194, P<0.001), and was lower in men (1.13±0.29%) than in women (1.20±0.31%, P=0.002). T/S ratio was positively associated with BMI in women (r=0.11, P=0.047), but not in men. The relationship between T/S ratio and surrogate markers of arterial stiffness and cardiovascular organ damage were not significant, except for CAAI, which was inversely associated with T/S ratio only in men (r=-0.159, P=0.015). However, T/S ratio was significantly associated with eGFR both in men and women (Figure).
Conclusions: In this study, telomere length was not associated with the measures of arterial stiffness and target organ damage, but was associated with renal function. While additional analyses are in progress, it is possible that in the Japanese population, telomere length may be a marker of renal aging rather than that cardiovascular disease.
Author Disclosures: K. Eguchi: None. L.S. Honig: None. J.H. Lee: None. S. Hoshide: None. K. Kario: None.
- © 2016 by American Heart Association, Inc.