Abstract 14495: HDL Dysfunction in Patients With Coronary Artery Disease and Previous Ischemic Cerebrovascular Event
Introduction: Patients with coronary artery disease (CAD) and history of ischemic stroke (IS) or transient ischemic attack (TIA) have a high risk of ischemic and hemorrhagic events. HDL cholesterol is a protective factor for ischemic events, and among its different functions lipids transfer, antioxidant, anti-inflammatory, antiplatelet and vasodilatory capacities are described. However, HDL function in patients with CAD and previous IS/TIA is poorly understood.
Hypothesis: A compromised HDL function would occur in pts with history of IS/ TIA which could explain, at least partially, the high risk of ischemic events observed in this population.
Methods: We included 140 stable CAD pts in a case-control study with (Case Group, n=70) or without (Control Group, n=70) previous IS/TIA, evaluated for transfer capacity of lipids by HDL. In vitro transfer of lipids was determined by 1 h incubation of a donor nanoemulsion containing radioactively labeled non-esterified and esterified cholesterol, phospholipids and triglycerides with whole plasma, followed by chemical precipitation and radioactive counting in the supernatant (HDL).
Results: The main results are described in the Table. As can be seen, individuals in the Case Group presented a significantly dysfunctional HDL regarding non-esterified cholesterol and triglycerides transfers by both, unadjusted and adjusted models.
Conclusions: The dysfunctional HDL observed in pts with previous IS/TIA is probably involved in the poor outcome observed in this population.
Author Disclosures: C.J. Barbosa: None. R.C. Maranhão: None. R.S. Barreiros: None. A. Franci: None. R.H. Furtado: None. F.B. Arantes: None. F.R. Sousa e Freitas: None. J.A. Ramires: None. R. Kalil-filho: None. J.C. Nicolau: None.
- © 2016 by American Heart Association, Inc.