Abstract 14486: Bariatric Surgery is Associated With Reduced Risk of Hospitalizations for Stable Angina Pectoris in Obese Adults
Introduction: Obesity and stable angina pectoris (SAP) are important public health problems in the U.S. There are potential pathophysiologic mechanisms that connect obesity to increased morbidity in patients with SAP. However, little is known about whether weight loss interventions, such as bariatric surgery, affect the risk of SAP-related morbidity.
Hypothesis: Bariatric surgery is associated with a reduced risk of hospitalizations for SAP in obese adults.
Methods: We performed a self-controlled case series study (each individual serves as his/her own control) of obese adults with SAP who underwent bariatric surgery, using a population-based inpatient database that recorded every bariatric surgery and hospitalization in 3 states (California, Florida, and Nebraska) from 2005 through 2011. The primary outcome was hospitalization for SAP. We used conditional logistic regression to compare each patient’s risk of the outcome event during sequential 12-month periods, using pre-surgery months 13-24 as a reference period.
Results: Our sample consisted of 953 patients with SAP who underwent bariatric surgery. During the reference period, 25.3% (95% confidence interval [CI], 22.5% 28.1%) of patients had a hospitalization for SAP. The risk of hospitalizations for SAP remained stable in the subsequent 12-month pre-surgery period (adjusted odds ratio [aOR] 0.84 [95%CI, 0.69-1.02]; P=0.07). In the first 12-month period after bariatric surgery, we observed a significantly reduced risk of hospitalizations for SAP (9.1% [95%CI, 7.3%-11.0%]; aOR 0.33 [95%CI, 0.26-0.43]; P<0.0001). Similarly, the risk remained significantly lower in the subsequent 13-24 months after bariatric surgery (8.7% [95%CI, 6.9%-10.5%]; aOR 0.31 [95%CI, 0.24-0.41]; P<0.0001).
Conclusion: In this population-based study of obese adults with SAP, we found that the risk of hospitalizations for SAP decreased by two-thirds after bariatric surgery.
Author Disclosures: Y.J. Shimada: None. Y. Tsugawa: None. H. Iso: None. D.F. Brown: None. K. Hasegawa: None.
- © 2016 by American Heart Association, Inc.