Abstract 14476: Vitamin D Level and Driveline Infection in Patients Undergoing Left Ventricular Assist Device Implantation
Introduction: Vitamin D has been identified as a hormone that acts on bone health and calcium homeostasis. It is also an important hormone that regulates cardiac myocytes. It has been implicated in the immune system and the inflammatory cascade led by B and T cells. Deficient levels of vitamin D have also been found to correlate with sepsis. Patients undergoing left ventricular assist device (LVAD) implantation are at increased risk of driveline infection. It is considered one of the major adverse events after LVAD implantation.
Hypothesis: Vitamin D levels are associated with increased risk of driveline infection after LVAD implantation.
Methods: We retrospectively reviewed the charts of 212 consecutive LVAD patients between Jan 1, 2010 and Jan 1, 2015. A total of 29 patients on ECMO and biventricular assist devices were excluded. Demographics showed a mean age of 59.7 years, 76.8% male and 52% Caucasian. We measured 25-OH vitamin D levels within one week prior to LVAD implantation and investigated its association with driveline infection during 1 year follow up. Vitamin D level was classified into 3 categories listed as Normal (>30 ng/ml), Insufficient (20-30 ng/ml) and Deficient (<20 ng/ml). The rate of driveline infection in the insufficient and deficient categories was compared to the normal category.
Results: Lower vitamin D levels were independently associated with a significant increase in the rate of driveline infection (Table 1).
Conclusions: In conclusion, these findings reflect the clinical impact of vitamin D levels on patients undergoing LVAD implantation. Patients with decreased vitamin D levels had a significant increase in driveline infection. This can result in increased readmissions and morbidity. Further studies are needed to determine if vitamin D repletion regimens could decrease driveline infections.
Author Disclosures: F. Abou Obeid: None. A. Rifai: None. A. Tatooles: None. E. Drever: None. G. Yost: None. G. Bhat: None.
- © 2016 by American Heart Association, Inc.