Abstract 14363: Thrombogenicity of Platinum-chromium Everolimus-eluting Stent is Comparable Low to that of Cobalt-chromium Everolimus-eluting Stent in the Subacute Phase of Acute Myocardial Infarction
Introduction: Population science has shown similar outcomes between the cobalt-chromium everolimus-eluting stent (CoCr-EES) and the platinum-chromium everolimus-eluting stent (PtCr-EES). CoCr-EES demonstrated a lower rate of early stent thrombosis compared to bare-metal stents in patients with acute myocardial infarction (AMI). However, subclinical intracoronary thrombus following the implantation of these stents in AMI has not been explored.
Methods: We performed coronary angioscopy 13±2 days after the stent implantation: 47 stents in 46 lesions from 42 patients with AMI (male 90%, mean age 64±13 years). The degree of thrombus adhesion and yellow plaque severity were compared between CoCr-EES (26 stents in 25 lesions from 22 patients) and PtCr-EES (21 stents in 21 lesions from 20 patients). The degree of thrombus adhesion was graded: grade 0 (none), no thrombus; grade 1 (focal), spotty thrombus; grade 2 (multi-focal), several spotty thrombi; grade 3 (diffuse), thrombus extending between the struts. Yellow plaque severity was graded: grade 0, white; grade 1, light yellow; grade 2, yellow; grade 3, bright yellow.
Results: Mean follow-up duration was similar between CoCr-EES and PtCr-EES (13±2 versus 13±2 days, P=0.17). Baseline characteristics were not statistically different except for diabetes mellitus (14% versus 45%, P=0.025). Thrombus grade was similar (Figure, P=0.49). Yellows plaque grade was also similar between CoCr-EES (grade 0, 0%; grade 1, 23%; grade 2, 19%; grade 3, 58%) and PtCr-EES (grade 0, 0%; grade 1, 19%; grade 2, 29%; grade 3, 52%, P=0.88).
Conclusions: Subclinical intracoronary thrombus was comparable between CoCr-EES and PtCr-EES in the subacute phase of AMI, associated with equally severe yellow plaque lesions. Thrombogenicity of PtCr-EES may be similarly low to that of CoCr-EES in patients with AMI.
Author Disclosures: T. Ishihara: None. O. Iida: None. M. Fujita: None. M. Masuda: None. S. Okamoto: None. K. Nanto: None. T. Kanda: None. A. Sunaga: None. T. Tsujimura: None. S. Okuno: None. Y. Matsuda: None. K. Yanaka: None. T. Ohashi: None. H. Kawai: None. A. Tsuji: None. Y. Hata: None. M. Uematsu: None.
- © 2016 by American Heart Association, Inc.