Abstract 14350: Hemoptysis as a Side Effect of Cryoballoon Pulmonary Vein Isolation in Atrial Fibrillation - A Retrospective Case-control Study
Introduction: Hemoptysis and pulmonary hemorrhage are rarely described as complications of cryoballoon ablation for pulmonary vein isolation (CB PVI). We aimed to evaluate a large single center cohort regarding frequency and possible risk factors for manifestation of these complications.
Hypothesis: Hemoptysis and pulmonary tissue injury are rare complications of cryoballoon pulmonary vein isolation.
Methods: Among 715 consecutive patients evaluated from a single center data base 4.3% (31 pts, 29 male, mean age 60.5 ± 11.5 years) were identified to have experienced hemoptysis following CB PVI.
Results: Comparison to 31 matched controls from the same cohort revealed significantly lower ablation temperatures in the case group for the right inferior pulmonary vein (PV) (case group: -56.2 ± 26.6 °C; control group: 49.1 ± 13.2 °C; p = 0.004) and left inferior PV(case group -56.4 ± 11.9 °C; control group 47.2 ± 7.6 °C; p = 0.001) in a univariate analysis. All other procedural parameters were found to be not significantly different between the groups. Although pre-procedural levels of hemoglobin were comparable, post-procedural hemoglobin was also lower in the case-group (case-group: 12.9 ± 1.6 g/dl; control-group: 13.7 ± 1.5 g/dl; p < 0.05). 26 pts presenting with hemoptysis underwent chest CT scan demonstrating perivenous infiltration at either the right inferior PV (n=23) or left inferior PV (n=2) or no infiltrate (n=1). No negative long-term effects were reported in follow-up scheduled at 3, 6, 12, 18 and 24 months.
Conclusions: Post-procedural hemoptysis after CB PVI seems to be a relatively frequent finding associated with low freezing temperatures and pulmonary tissue infiltration predominantly located at the right inferior PV.
Author Disclosures: K. Bullert: None. K. Gutleben: Other; Modest; Travel reimbursment by Biotronik. D. Horstkotte: None. S. Molatta: None. B. Körber: None. G. Noelker: None.
- © 2016 by American Heart Association, Inc.